| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | S100 alpha6; Protein S100-A6; Calcyclin; MLN 4; PRA; CACY; CABP; 5B10 |
| Entrez GeneID | 6277 |
| WB Predicted band size | Calculated MW: 10 kDa; Observed MW: 10 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Recombinant protein of human S100 alpha 6/PRA |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于S100A6抗体的模拟参考文献示例(内容为虚构，仅供格式参考)：
1. **文献名称**: *S100A6 Antibody-Based Detection in Pancreatic Cancer: A Diagnostic Tool*
**作者**: Smith JR, et al.
**摘要**: 研究验证了S100A6抗体的特异性，发现其在胰腺癌组织中的高表达可作为早期诊断标志物，通过免疫组化(IHC)证实了其临床相关性。
2. **文献名称**: *S100A6 as a Prognostic Marker in Colorectal Cancer: Validation via Western Blot*
**作者**: Li X, Wang Y.
**摘要**: 利用S100A6抗体进行蛋白质印迹分析，发现其在结直肠癌患者中的表达水平与肿瘤转移和生存率降低显著相关。
3. **文献名称**: *Targeting S100A6 with Monoclonal Antibodies: Implications for Cancer Therapy*
**作者**: García M, et al.
**摘要**: 开发了针对S100A6的单克隆抗体，体外实验显示其能抑制肿瘤细胞增殖，提示其作为靶向治疗药物的潜力。
4. **文献名称**: *S100A6 Antibody Cross-Reactivity Analysis Across Species*
**作者**: Tanaka K, et al.
**摘要**: 评估了S100A6抗体在小鼠、大鼠及人类样本中的交叉反应性，证实其在跨物种研究中的适用性，为动物模型提供实验依据。
(注：以上文献为模拟生成，实际引用需查询真实数据库如PubMed。)
The S100A6 antibody is a key tool for detecting S100A6. a calcium-binding protein belonging to the S100 family. S100A6. also known as calcyclin, is encoded by the *S100A6* gene and is involved in diverse cellular processes, including cell cycle progression, differentiation, calcium signaling, and cytoskeletal dynamics. It is highly expressed in various tissues, such as the brain, pancreas, and skin, and its dysregulation has been linked to cancers (e.g., pancreatic, melanoma), neurodegenerative disorders, and inflammatory conditions.
S100A6 antibodies, typically raised in rabbits or mice, are designed to recognize specific epitopes of the S100A6 protein. These antibodies are widely used in research applications like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study S100A6’s localization, expression levels, and interactions with binding partners (e.g., calmodulin, annexins). Their specificity is validated through knockout controls or siRNA-based silencing to ensure accurate detection.
In clinical contexts, S100A6 antibodies have potential diagnostic utility, as elevated S100A6 levels correlate with tumor aggressiveness and metastasis in certain cancers. Additionally, they aid in exploring S100A6’s role in stress responses, where it modulates apoptosis and inflammation. Despite progress, challenges remain in standardizing cross-reactivity across species and optimizing protocols for quantitative assays. Overall, S100A6 antibodies are vital for unraveling the protein’s multifaceted roles in health and disease.
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