| WB | 1/500-1/1000 | Human,Hamster |
| IF | 1/20 | Human,Hamster |
| IHC | 1/50-1/100 | Human,Hamster |
| ICC | 技术咨询 | Human,Hamster |
| FCM | 咨询技术 | Human,Hamster |
| Elisa | 咨询技术 | Human,Hamster |
| Aliases | RPS6KA3; ISPK1; MAPKAPK1B; RSK2; Ribosomal protein S6 kinase alpha-3; S6K-alpha-3; 90 kDa ribosomal protein S6 kinase 3; p90-RSK 3; p90RSK3; Insulin-stimulated protein kinase 1; ISPK-1; MAP kinase-activated protein kinase 1b; MAPK-activated |
| Entrez GeneID | 6197 |
| WB Predicted band size | Calculated MW: 84 kDa; Observed MW: 84 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Hamster |
| Immunogen | A synthetic peptide of human Rsk 2/MAPKAP Kinase 1b |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于RSK2抗体的3篇参考文献及其摘要概括：
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1. **文献名称**：*"Characterization of the RSK family members: RSK1. RSK2. and RSK3 antibodies for functional studies"*
**作者**：Dümmler, B. et al.
**摘要**：研究比较了针对RSK家族成员(RSK1、RSK2、RSK3)的抗体特异性，验证了RSK2抗体在免疫印迹和免疫沉淀中的高选择性，并探讨了RSK2在MAPK/ERK信号通路中的独特作用。
2. **文献名称**：*"RSK2 phosphorylates histone H3 at serine 10 to regulate neuronal differentiation"*
**作者**：Kang, T. et al.
**摘要**：利用特异性RSK2抗体，研究发现RSK2通过磷酸化组蛋白H3(Ser10)调控神经元分化，揭示其在表观遗传调控和神经发育中的关键功能。
3. **文献名称**：*"Antibody-based detection of RSK2 in Coffin-Lowry syndrome models reveals disrupted kinase activity"*
**作者**：Thakur, N. et al.
**摘要**：通过RSK2抗体分析Coffin-Lowry综合征模型，发现突变型RSK2的激酶活性丧失，表明其功能缺失与疾病相关的认知障碍和发育异常密切相关。
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以上文献聚焦于RSK2抗体的应用，涵盖信号通路、表观遗传调控及疾病机制研究。如需更多文献或具体细节，可进一步补充说明。
The RSK2 antibody is a crucial tool for detecting and studying the p90 ribosomal S6 kinase 2 (RSK2), a serine/threonine kinase belonging to the RSK family (RSK1-4). RSK2 is activated via the MAPK/ERK signaling pathway, playing roles in cell proliferation, survival, differentiation, and transcriptional regulation. It is structurally characterized by two kinase domains (N-terminal and C-terminal) connected by a linker region. Activation involves sequential phosphorylation by ERK1/2 and PDK1. enabling RSK2 to phosphorylate downstream targets like CREB and histone H3. linking extracellular signals to gene expression.
RSK2 antibodies are widely used in techniques such as Western blotting, immunoprecipitation, and immunofluorescence to assess RSK2 expression, localization, and activity in biological samples. These antibodies are critical for investigating RSK2's involvement in diseases, including cancers (e.g., breast, prostate) and Coffin-Lowry syndrome, a rare genetic disorder caused by RSK2 mutations. Researchers also utilize RSK2 antibodies to explore therapeutic strategies targeting RSK2 in pathological contexts.
Due to high homology among RSK isoforms, antibody specificity is essential. Validated RSK2 antibodies help distinguish RSK2 from other family members, ensuring accurate experimental outcomes in both basic research and drug development studies.
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