| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | ASB; ANH1; XLSA; ALASE; XLDPP; XLEPP; ALAS-E |
| WB Predicted band size | 64 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human ALAS2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于RBM3抗体的3篇参考文献示例(文献信息为虚构，仅供格式参考)：
1. **文献名称**：*RBM3 as a potential biomarker in breast cancer: Expression and clinical significance*
**作者**：Jögi A, et al.
**摘要**：研究通过免疫组化使用RBM3抗体分析乳腺癌组织样本，发现RBM3高表达与患者生存率改善相关，提示其可能作为预后标志物。
2. **文献名称**：*Cold-induced RBM3 expression mediates neuroprotection in a mouse model of hypothermia*
**作者**：Chip S, et al.
**摘要**：通过Western blot和免疫荧光技术，利用RBM3抗体证明低温诱导的RBM3蛋白上调可减少神经元凋亡，揭示其在神经保护中的作用机制。
3. **文献名称**：*RBM3 antibody validation for RNA-binding studies in colorectal cancer cells*
**作者**：Drescher B, et al.
**摘要**：研究验证了多种RBM3抗体的特异性，并通过RNA免疫沉淀实验(RIP)证实RBM3与特定mRNA的结合，为结直肠癌中的RNA调控研究提供工具支持。
注：以上文献为示例，实际引用需根据真实研究补充具体信息。
The RNA-binding motif protein 3 (RBM3) antibody is a key tool for studying the RBM3 protein, a member of the RNA-binding glycine-rich family involved in transcriptional and post-transcriptional regulation. RBM3 is evolutionarily conserved and structurally characterized by an RNA-recognition motif (RRM) and a glycine-rich domain, enabling interactions with RNA and other proteins. It plays roles in mRNA stability, splicing, and translation, particularly under stress conditions such as hypothermia, hypoxia, or nutrient deprivation. Notably, RBM3 is a cold-inducible protein, upregulated in response to mild hypothermia, where it promotes cell survival and inhibits apoptosis.
Research highlights its dual context-dependent roles in cancer: it acts as a tumor suppressor in some malignancies (e.g., colorectal cancer) by enhancing apoptosis, while functioning as an oncogene in others (e.g., neuroblastoma) by supporting proliferation. RBM3 is also implicated in neuroprotection, with studies linking its expression to reduced neurodegeneration in Alzheimer’s disease models.
RBM3 antibodies are widely used in techniques like immunohistochemistry, Western blotting, and immunofluorescence to assess protein expression patterns in tissues or cultured cells. Commercial antibodies are available from multiple suppliers, often validated for specificity across human, mouse, and rat samples. Due to RBM3's association with cellular stress responses and disease mechanisms, its antibody serves as a critical reagent in exploring therapeutic targets, prognostic biomarkers, and molecular pathways in cancer, neurology, and regenerative medicine.
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