| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | RAB7L; RAB7L1 |
| Entrez GeneID | 8934 |
| WB Predicted band size | Calculated MW: 23 kDa; Observed MW: 23 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Recombinant protein of human RAB29 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是3篇关于Rab29抗体的参考文献摘要概括：
1. **"Rab29 modulates the extension of primary cilia in the developing mouse brain"**
*作者：Shimizu et al. (2021)*
摘要：研究使用Rab29特异性抗体揭示其在初级纤毛形成中的作用，发现Rab29通过调控纤毛膜蛋白运输影响小鼠大脑皮层发育。
2. **"LRRK2 phosphorylation by Rab29-linked kinases promotes Golgi fragmentation"**
*作者：Purlyte et al. (2018)*
摘要：通过Rab29抗体进行免疫共沉淀实验，证明Rab29招募LRRK2至反式高尔基体，介导其磷酸化并导致神经退行性疾病相关的细胞结构异常。
3. **"Rab29-dependent trafficking of the dopamine transporter in Parkinson's models"**
*作者：Navaroli et al. (2019)*
摘要：利用Rab29抗体进行免疫荧光染色，发现Rab29缺失导致多巴胺转运体内吞障碍，提示其与帕金森病病理中突触功能失调相关。
*注：文献信息为模拟示例，实际引用需核对真实数据库(如PubMed)。如需具体文献，建议检索关键词“Rab29 antibody”并筛选实验应用明确的研究。*
Rab29. a member of the Rab GTPase family, plays a critical role in regulating intracellular membrane trafficking and vesicle transport. It is closely associated with the endolysosomal system and autophagy pathways, with emerging links to neurodegenerative diseases, particularly Parkinson’s disease (PD). Rab29. also known as Rab7L1. has been identified as a key interactor of leucine-rich repeat kinase 2 (LRRK2), a protein frequently mutated in familial and sporadic PD cases. Dysregulation of Rab29-LRRK2 interactions is implicated in pathogenic mechanisms, including impaired lysosomal function and neurite outgrowth.
Antibodies targeting Rab29 are essential tools for studying its expression, localization, and function in cellular and disease models. These antibodies enable researchers to detect Rab29 in tissues or cell lines via techniques like Western blotting, immunofluorescence, or immunohistochemistry. Specific Rab29 antibodies help elucidate its role in modulating LRRK2 kinase activity, membrane recruitment, and downstream signaling pathways. Additionally, they aid in exploring Rab29’s involvement in autophagy-lysosomal dysfunction, a hallmark of neurodegenerative disorders.
Recent studies highlight Rab29’s potential as a therapeutic target or biomarker for PD, driving demand for high-specificity antibodies. Validation of these reagents is critical to ensure accurate detection, given the high homology among Rab GTPases. Overall, Rab29 antibodies contribute significantly to advancing our understanding of cellular trafficking mechanisms and their disruption in disease.
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