首页 / 产品 / 抗体 / 一抗

Rabbit Monoclonal PTP4A2 Antibody

  • 中文名： PTP4A2抗体
  • 别    名： protein tyrosine phosphatase type IVA; member 2; HH13; OV-1; PRL2; HH7-2; PRL-2; PTP4A; HU-PP-1; PTPCAAX2; ptp-IV1a; ptp-IV1b
货号: IPDX22542
Price： ￥1280
数量：
大包装询价

验证与应用

应用及物种
WB 1/500-1/1000 Human,Mouse,Rat
IF 1/20 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

Aliasesprotein tyrosine phosphatase type IVA; member 2; HH13; OV-1; PRL2; HH7-2; PRL-2; PTP4A; HU-PP-1; PTPCAAX2; ptp-IV1a; ptp-IV1b
Entrez GeneID8073
WB Predicted band sizeCalculated MW: 19 kDa; Observed MW: 19 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenA synthetic peptide of human PTP4A2/PRL2
FormulationPurified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

+ +

参考文献

以下是3篇与PTP4A2抗体相关的虚构参考文献示例(注：文献信息为模拟创作，仅供格式参考)：

1. **"PTP4A2 regulates cell migration through tyrosine dephosphorylation of focal adhesion kinase"**

*Authors: Chen L, Wang X, Zhang H*

摘要：研究揭示了PTP4A2通过去磷酸化黏着斑激酶(FAK)调控肿瘤细胞迁移的机制，使用特异性抗体证实其在结肠癌细胞中的亚细胞定位及相互作用。

2. **"Overexpression of PTP4A2 correlates with poor prognosis in hepatocellular carcinoma"**

*Authors: Tanaka K, Suzuki R, Nakamura Y*

摘要：通过免疫组化分析肝癌组织样本，发现PTP4A2蛋白高表达与患者生存期缩短显著相关，提示其作为肝癌预后生物标志物的潜在价值。

3. **"Development of a novel monoclonal antibody for detecting PTP4A2 in human serum samples"**

*Authors: Müller S, Fischer J, Weber T*

摘要：报道了一种高灵敏度的抗PTP4A2单克隆抗体的制备及验证，成功应用于ELISA检测，证实其在乳腺癌患者血清中表达水平显著升高。

(提示：真实文献需通过PubMed/Google Scholar检索关键词"PTP4A2 antibody"获取)

背景信息

The PTP4A2 antibody is a research tool designed to detect and study the protein tyrosine phosphatase 4A2 (PTP4A2), a member of the PRL (phosphatase of regenerating liver) phosphatase family. PTP4A2. also known as PRL-2. is encoded by the PTP4A2 gene and plays a role in cellular signaling pathways regulating proliferation, migration, and metastasis. This small, prenylated phosphatase contains a conserved CAAX motif at its C-terminus, enabling post-translational lipid modification for membrane association. PTP4A2 is implicated in cancer progression, with overexpression observed in colorectal, ovarian, and other malignancies, correlating with poor prognosis. Its enzymatic activity modulates downstream targets involved in cell cycle control and cytoskeletal dynamics. The PTP4A2 antibody is widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess protein expression, localization, and dysregulation in disease models. Researchers employ it to investigate PTP4A2's role in oncogenesis, its interaction partners, and potential as a therapeutic target. Validation typically includes testing in knockout cell lines or tissues to confirm specificity, given high sequence homology among PRL family members (PTP4A1-3).

客户数据及评论

折叠内容

大包装询价

×