| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Homeobox protein OTX1 (Orthodenticle homolog 1) |
| Entrez GeneID | 5013 |
| WB Predicted band size | Calculated MW: 37 kDa; Observed MW: 37 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthetic peptide of human Otx1 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于OTX1抗体的3篇参考文献(根据公开文献整理，部分信息为模拟示例)：
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1. **文献名称**: *OTX1 Transcription Factor as a Potential Biomarker in Glioblastoma: Immunohistochemical Analysis*
**作者**: Smith A, et al.
**摘要**: 本研究利用OTX1特异性抗体，通过免疫组化技术分析其在胶质母细胞瘤组织中的表达。结果显示，OTX1在肿瘤细胞核内高表达，且与患者预后不良相关，提示其可作为潜在的诊断标志物和治疗靶点。
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2. **文献名称**: *Developmental Role of OTX1 in Mouse Cerebral Cortex: Insights from Antibody-Based Knockdown*
**作者**: Chen L, et al.
**摘要**: 通过OTX1抗体介导的功能抑制实验，发现OTX1在小鼠大脑皮层发育中调控神经元迁移和分层。Western blot和免疫荧光证实OTX1蛋白在胚胎期皮层中动态表达，支持其在神经发育中的关键作用。
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3. **文献名称**: *OTX1 Expression in Retinoblastoma: Correlation with Tumor Aggressiveness*
**作者**: Gupta R, et al.
**摘要**: 本研究采用OTX1单克隆抗体检测视网膜母细胞瘤样本，发现OTX1高表达与肿瘤侵袭性及转移风险显著相关。结果提示OTX1可能通过调控细胞周期相关基因促进肿瘤进展。
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**注意**：以上文献为示例，实际研究中建议通过PubMed或Google Scholar以关键词“OTX1 antibody”或“OTX1 immunohistochemistry”检索最新文献，并优先选择近5年内的研究。部分经典文献可能需要通过抗体生产商(如Abcam、CST)官网的技术支持页面获取引用信息。
The OTX1 antibody is a crucial tool in studying the Orthodenticle homeobox 1 (OTX1) protein, a transcription factor belonging to the bicoid class of homeodomain-containing proteins. OTX1 plays a pivotal role in embryonic development, particularly in the brain, sensory organs, and pituitary gland. It is involved in regional patterning of the forebrain and midbrain, as well as retinal development. Dysregulation of OTX1 has been linked to various cancers, including glioblastoma, medulloblastoma, and prostate cancer, where it may act as an oncogene by promoting cell proliferation or inhibiting differentiation.
Researchers use OTX1 antibodies primarily for immunohistochemistry (IHC), Western blotting (WB), and immunofluorescence (IF) to detect protein expression patterns in tissues or cell lines. These antibodies help investigate OTX1's role in developmental biology and tumorigenesis, including its potential as a diagnostic marker or therapeutic target. Validation often includes knockout controls to confirm specificity. Commercial OTX1 antibodies are typically raised in rabbits or mice against specific epitopes of the human OTX1 protein. Recent studies also explore its involvement in neurological disorders and retinal degeneration, expanding its research relevance across developmental and disease contexts.
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