首页 / 产品 / 抗体 / 一抗

Rabbit Monoclonal NSDHL Antibody

  • 中文名: NSDHL抗体
  • 别    名: H105E3; XAP104; SDR31E1
货号: IPDX22491
Price: ¥1280
数量:
大包装询价

验证与应用

应用及物种
WB 1/500-1/1000 Human,Mouse,Rat
IF 1/20 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesH105E3; XAP104; SDR31E1
Entrez GeneID50814
WB Predicted band sizeCalculated MW: 42 kDa; Observed MW: 42 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenA synthetic peptide of human NSDHL
FormulationPurified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

+ +

参考文献

以下是3篇关于NSDHL抗体的参考文献(信息为示例性概括,实际文献需根据具体数据库核实):

---

1. **文献名称**:*"NSDHL mutations underlie CHILD syndrome development: Immunohistochemical analysis in epidermal models"*

**作者**:Calienes, M.F., et al.

**摘要**:通过免疫组化技术,研究NSDHL基因突变对皮肤胆固醇代谢的影响,发现NSDHL抗体标记的蛋白表达缺失与CHILD综合征(先天性半侧发育不良)的病理机制相关。

---

2. **文献名称**:*"Targeting NSDHL in cancer: Antibody-based detection of cholesterol synthesis enzyme overexpression"*

**作者**:Huang, Y., et al.

**摘要**:利用NSDHL特异性抗体分析多种癌细胞系,证实NSDHL在肿瘤中高表达,并揭示其通过调控胆固醇合成促进癌细胞增殖的分子通路。

---

3. **文献名称**:*"Functional characterization of NSDHL in embryonic development using knockout mouse models"*

**作者**:Braverman, N., et al.

**摘要**:通过NSDHL抗体在小鼠胚胎组织中的免疫荧光染色,发现NSDHL缺失导致胚胎发育异常,强调其在甾醇代谢和神经系统形成中的关键作用。

---

**注**:以上为模拟示例,实际文献需通过PubMed、Web of Science等平台以“NSDHL antibody”为关键词检索获取。部分经典研究可能涉及NSDHL的遗传学或代谢功能,但明确使用抗体的文献需结合实验方法部分确认。

背景信息

The NSDHL (NAD(P)H steroid dehydrogenase-like protein) antibody is a tool used to detect the NSDHL enzyme, which plays a critical role in cholesterol biosynthesis. NSDHL is a membrane-bound oxidoreductase involved in the post-squalene cholesterol synthesis pathway, specifically catalyzing the C-4 demethylation step of lanosterol. This enzyme is encoded by the *NSDHL* gene located on the X chromosome (Xq28). Mutations in *NSDHL* are linked to human genetic disorders such as CHILD syndrome (Congenital Hemidysplasia with Ichthyosiform Erythroderma and Limb Defects) and CK syndrome, characterized by skeletal, skin, and neurological abnormalities due to disrupted cholesterol metabolism.

The NSDHL antibody is widely utilized in research to study cholesterol biosynthesis, lipid metabolism, and associated diseases. It helps identify NSDHL expression levels, subcellular localization (primarily in the endoplasmic reticulum), and functional alterations in cellular or tissue samples. Researchers also employ this antibody to investigate NSDHL's role in cancer, as cholesterol dysregulation is implicated in tumor progression. Studies suggest NSDHL may influence cell signaling and membrane structure in malignancies. Additionally, the antibody aids in exploring therapeutic targets for metabolic disorders or cancers linked to cholesterol pathway anomalies. Its specificity and reliability make it a valuable tool in both basic and translational research contexts.

客户数据及评论

折叠内容

大包装询价

×