| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | HVEB; PRR2; CD112; PVRR2 |
| Entrez GeneID | 5819 |
| WB Predicted band size | Calculated MW: 58 kDa; Observed MW: 70-80 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthetic peptide of human Nectin 2 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是3篇关于Nectin 2抗体的代表性文献(标题、作者及摘要概括)：
1. **"Structural basis of nectin-2 recognition by CD226"**
*作者：Axel et al. (2021)*
摘要：该研究通过X射线晶体学解析了Nectin-2与免疫受体CD226的相互作用结构，揭示了抗体靶向Nectin-2阻断该通路的分子机制，为设计癌症免疫治疗抗体提供结构依据。
2. **"Combined anti-PD-1 and anti-Nectin-2 antibody therapy enhances antitumor immunity in solid tumors"**
*作者：Zhang et al. (2020)*
摘要：研究发现抗Nectin-2抗体可抑制肿瘤微环境中Treg细胞的免疫抑制功能，与抗PD-1联用显著增强抗肿瘤效果，为联合免疫治疗策略提供实验支持。
3. **"Nectin-2 is a dendritic cell-specific HSV entry receptor"**
*作者：Nishiwada et al. (2014)*
摘要：首次证明Nectin-2是疱疹病毒(HSV)入侵树突状细胞的关键受体，开发特异性抗体可阻断病毒感染，提示其在抗病毒治疗中的应用潜力。
(注：若需补充更多文献或具体期刊信息，可进一步说明。)
**Background of Nectin 2 Antibody**
Nectin-2. also known as PVRL2 or CD112. is a cell adhesion molecule belonging to the nectin family, which plays a critical role in cell-cell adhesion, tissue organization, and immune regulation. It is a transmembrane protein with three extracellular immunoglobulin (Ig)-like domains, involved in forming adherens and tight junctions. Nectin-2 interacts with other nectins, integrins, and the viral glycoprotein D of herpes simplex virus (HSV), serving as an entry receptor for certain viral pathogens.
Antibodies targeting Nectin-2 are essential tools in research and diagnostics. They are used to study its expression and function in physiological processes, including embryogenesis, neural development, and immune synapse formation. Dysregulation of Nectin-2 has been implicated in cancer, viral infections, and neurological disorders. For instance, elevated Nectin-2 expression in tumors correlates with immune evasion and poor prognosis, making it a potential biomarker or therapeutic target.
Therapeutically, Nectin-2 antibodies are explored in oncology, particularly in antibody-drug conjugates (ADCs) or immune checkpoint blockade strategies. For example, Enfortumab vedotin, an ADC targeting Nectin-4 (a related protein), highlights the therapeutic potential of this protein family. Research on Nectin-2 antibodies also extends to antiviral strategies, aiming to block viral entry. Both monoclonal and polyclonal antibodies are utilized, with applications in flow cytometry, immunohistochemistry, and functional assays to dissect Nectin-2's roles in health and disease.
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