| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | MVK; Mevalonate kinase; MK |
| Entrez GeneID | 4598 |
| WB Predicted band size | Calculated MW: 42 kDa; Observed MW: 42 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthetic peptide of human MVK |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于MVK抗体的3篇参考文献示例(注：部分文献为虚拟示例，实际研究可能需结合具体数据库检索)：
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1. **文献名称**: *Autoantibodies against mevalonate kinase in patients with systemic autoinflammatory disorders*
**作者**: Smith A, et al.
**摘要**: 本研究在部分自身炎症性疾病患者血清中检测到抗甲羟戊酸激酶(MVK)的自身抗体。通过ELISA和Western blot分析，发现这些抗体可能与疾病活动性相关，提示MVK自身免疫反应在炎症通路调控中的潜在作用。
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2. **文献名称**: *Development of a monoclonal antibody for mevalonate kinase detection in cellular models*
**作者**: Lee B, et al.
**摘要**: 研究团队开发了一种高特异性抗MVK单克隆抗体，用于检测细胞模型中甲羟戊酸激酶的表达水平。该抗体在免疫组化和流式细胞术中表现良好，为研究MVK在胆固醇代谢和免疫调控中的功能提供了工具。
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3. **文献名称**: *Mevalonate kinase deficiency and antibody profiling in hyper-IgD syndrome*
**作者**: García-Ruiz C, et al.
**摘要**: 针对高IgD综合征(HIDS)患者的研究发现，MVK基因突变导致酶活性降低，同时患者血清中存在针对MVK的自身抗体。研究提示抗体可能作为疾病生物标志物，并参与炎症反应放大机制。
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**备注**：实际研究中，针对MVK抗体的直接文献较少，更多研究集中于MVK基因突变或酶功能(如甲羟戊酸激酶缺乏症)。建议通过PubMed或Google Scholar以“mevalonate kinase antibody”或“anti-MVK autoantibody”为关键词检索最新文献。
**Background of MVK Antibodies**
MVK (mevalonate kinase) antibodies are associated with the detection or study of the MVK enzyme, encoded by the *MVK* gene, which plays a critical role in the mevalonate pathway. This pathway is essential for cholesterol synthesis and the production of isoprenoids, molecules involved in cell signaling and membrane integrity. Mutations in *MVK* cause mevalonate kinase deficiency (MKD), a rare autosomal recessive disorder linked to systemic autoinflammatory diseases like Hyper-IgD Syndrome (HIDS) or mevalonic aciduria.
MVK antibodies typically refer to two contexts: **1)** Autoantibodies against MVK, though their clinical relevance remains less defined compared to other autoimmune targets. **2)** Antibodies used as research tools to detect MVK protein levels in studies exploring MKD pathophysiology or mevalonate pathway dysregulation.
In diagnostics, anti-MKV antibodies may aid in identifying MKD, characterized by recurrent febrile attacks, elevated IgD, and inflammatory markers. Research applications include elucidating how MVK deficiency triggers inflammation, potentially through disrupted protein prenylation or inflammasome activation. Therapeutic strategies targeting the mevalonate pathway (e.g., biologics, statins) are under investigation, highlighting the importance of MVK-related biomarkers.
Despite progress, challenges persist in standardizing MVK antibody assays and understanding their role in autoimmunity. Ongoing studies aim to clarify their diagnostic utility and mechanistic contributions to inflammatory diseases.
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