| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | AF17 |
| Entrez GeneID | 4302 |
| WB Predicted band size | Calculated MW: 112 kDa; Observed MW: 112 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Recombinant protein of human MLLT6 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是3篇涉及MLLT6(AF17)抗体的文献摘要信息：
1. **文献名称**：*The role of MLLT6 in DOT1L-mediated transcriptional regulation*
**作者**：Okuda H et al.
**摘要**：本研究利用MLLT6特异性抗体，通过ChIP-seq和免疫共沉淀技术，揭示了MLLT6作为DOT1L组蛋白甲基转移酶复合物的关键成员，在白血病细胞中调控H3K79甲基化及靶基因转录的作用。
2. **文献名称**：*AF17 facilitates embryonic stem cell differentiation by modulating Wnt/β-catenin signaling*
**作者**：Chen J et al.
**摘要**：通过Western blot和免疫荧光实验，作者发现MLLT6抗体标记的蛋白在小鼠胚胎干细胞分化过程中与β-catenin相互作用，调控Wnt信号通路活性，影响中胚层谱系定向。
3. **文献名称**：*Proteomic analysis of MLLT6-containing protein complexes in AML*
**作者**：Smith LM et al.
**摘要**：该研究使用MLLT6抗体进行免疫沉淀-质谱分析，鉴定出MLLT6在急性髓系白血病(AML)中与MLL1融合蛋白形成复合物，促进HOX基因异常表达及白血病细胞增殖。
注：以上文献为示例性内容，实际文献需通过PubMed或Google Scholar检索确认。建议使用关键词“MLLT6 antibody”或“AF17 antibody”结合研究领域(如白血病、表观遗传)进一步筛选。
The MLLT6 antibody targets the protein encoded by the *MLLT6* gene (Mixed Lineage Leukemia Translocated To 6), also known as *AF17*, located on chromosome 17q12. MLLT6 is a member of the MLL (KMT2A) gene translocation partner family, frequently involved in chromosomal rearrangements associated with acute leukemias, particularly acute myeloid leukemia (AML). These translocations, such as t(11;17)(q23;q12), fuse MLLT6 with the MLL gene, generating oncogenic fusion proteins that disrupt epigenetic regulation and transcriptional control, promoting leukemogenesis.
The MLLT6 protein is implicated in chromatin remodeling and transcriptional elongation, potentially interacting with components of the super elongation complex (SEC) to modulate RNA polymerase II activity. Its role in normal cellular processes remains less defined but may involve hematopoietic differentiation and cell cycle regulation.
MLLT6 antibodies are essential tools in research to detect endogenous MLLT6 protein expression, assess its localization (nuclear), and study its interaction partners or post-translational modifications. They are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry (IHC) to investigate MLLT6's involvement in leukemia pathogenesis and its potential as a diagnostic marker or therapeutic target. Commercial antibodies are typically validated for specificity and sensitivity, with applications spanning basic research and clinical studies exploring MLL rearrangement-driven malignancies.
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