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Rabbit Monoclonal IQGAP2 Antibody

  • 中文名： IQGAP2抗体
  • 别    名： Ras GTPase-activating-like protein IQGAP2
货号: IPDX22420
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 1/500-1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/50-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesRas GTPase-activating-like protein IQGAP2
Entrez GeneID10788
WB Predicted band sizeCalculated MW: 181 kDa; Observed MW: 181 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenRecombinant protein of human IQGAP2
FormulationPurified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

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参考文献

以下是关于IQGAP2抗体的3篇参考文献示例(注：文献为虚构示例，实际引用需核实)：

1. **文献名称**：*"IQGAP2 regulates cell proliferation and apoptosis in hepatocellular carcinoma via Akt pathway"*

**作者**：Zhang Y, et al.

**摘要**：本研究利用特异性IQGAP2抗体进行Western blot和免疫组化分析，发现IQGAP2在肝癌组织中表达显著下调，并通过调控Akt信号通路抑制肿瘤细胞增殖并促进凋亡。

2. **文献名称**：*"Characterization of a novel polyclonal antibody against human IQGAP2 and its application in cytoskeletal studies"*

**作者**：Wang L, et al.

**摘要**：文章报道了一种新型多克隆IQGAP2抗体的开发与验证，通过免疫荧光和共沉淀实验证实该抗体可特异性识别IQGAP2蛋白，并揭示其与F-actin的相互作用机制。

3. **文献名称**：*"IQGAP2 deficiency disrupts hepatic bile acid metabolism in mice"*

**作者**：Tanaka K, et al.

**摘要**：通过IQGAP2抗体对敲除小鼠肝组织进行蛋白定位分析，发现IQGAP2缺失导致胆汁酸转运蛋白表达异常，提示其在肝脏代谢稳态中的关键作用。

如需实际文献，建议通过PubMed或Google Scholar搜索关键词“IQGAP2 antibody”获取近期研究。

背景信息

The IQGAP2 antibody is a research tool used to study the IQ motif-containing GTPase-activating protein 2 (IQGAP2), a member of the IQGAP family of scaffolding proteins. IQGAP2 regulates cellular processes such as cytoskeletal dynamics, cell adhesion, and signal transduction by interacting with Rho GTPases (e.g., Cdc42. Rac1), calmodulin, and components of the Wnt/β-catenin pathway. Unlike IQGAP1. which is ubiquitously expressed and linked to cancer progression, IQGAP2 is predominantly found in the liver, pancreas, and gastrointestinal tissues, where it plays roles in maintaining tissue homeostasis and suppressing tumorigenesis. Studies associate IQGAP2 loss with hepatocellular carcinoma (HCC) and colorectal cancer, suggesting its tumor-suppressive function. The antibody enables detection of IQGAP2 expression levels and subcellular localization via techniques like Western blotting, immunohistochemistry, and immunofluorescence. It is critical for investigating IQGAP2's physiological and pathological roles, including its interplay with metabolic pathways (e.g., insulin signaling) and its potential as a biomarker or therapeutic target. However, cross-reactivity with other IQGAP isoforms (e.g., IQGAP1/3) remains a validation challenge. Commercial IQGAP2 antibodies are typically raised against specific epitopes, such as the N-terminal or C-terminal regions, to ensure target specificity. Ongoing research aims to clarify IQGAP2's dual roles in health and disease, leveraging antibody-based assays to explore its molecular mechanisms.

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