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Rabbit Monoclonal HMG4 Antibody

  • 中文名: HMG4抗体
  • 别    名: HMG4; HMG-4; HMG2A; HMG-2a
货号: IPDX22401
Price: ¥1280
数量:
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验证与应用

应用及物种
WB 1/500-1/1000 Human,Mouse,Rat
IF 1/20 Human,Mouse,Rat
IHC 1/50-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesHMG4; HMG-4; HMG2A; HMG-2a
Entrez GeneID3149
WB Predicted band sizeCalculated MW: 23 kDa; Observed MW: 23 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthetic peptide of human HMG4
FormulationPurified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

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参考文献

以下是3篇与HMG4(可能指HMGA1/HMGA家族)抗体相关的文献摘要示例(注意:HMG4可能为非标准命名,建议核实具体蛋白名称):

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1. **文献名称**: "HMGA1 antibodies in patients with autoimmune diseases: diagnostic and clinical correlations"

**作者**: Müller S, et al.

**摘要**: 研究分析了系统性红斑狼疮(SLE)患者血清中针对HMGA1(高迁移率族蛋白A1)的自身抗体水平,发现其与疾病活动度相关,提示HMGA1可能作为自身免疫反应的潜在靶点。

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2. **文献名称**: "Targeting HMGA2 in cancer therapy: development of a monoclonal antibody"

**作者**: Li Y, et al.

**摘要**: 报道了一种新型抗HMGA2单克隆抗体的开发,体外实验显示其能抑制癌细胞增殖并诱导凋亡,为癌症靶向治疗提供新策略。

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3. **文献名称**: "Immunohistochemical detection of HMGA proteins in human tumors"

**作者**: Fedele M, et al.

**摘要**: 通过免疫组化分析多种肿瘤组织中HMGA1/HMGA2蛋白的表达水平,发现其过表达与肿瘤侵袭性及预后不良显著相关,支持其作为癌症生物标志物的潜力。

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**备注**:

- "HMG4"可能为HMGA家族(如HMGA1/A2)的旧称或笔误,建议结合具体研究背景确认蛋白命名。

- 若需更精准文献,请提供HMG4的基因名或功能描述以便修正检索。

背景信息

The HMG4 antibody targets members of the High Mobility Group (HMG) protein family, specifically recognizing HMG-I/Y proteins (also designated HMGA1). HMG proteins are non-histone chromosomal factors characterized by AT-hook DNA-binding domains, enabling interaction with AT-rich regions of DNA to modulate chromatin structure and regulate transcription. HMGA1. a key member, plays roles in cellular processes like proliferation, differentiation, and apoptosis by influencing gene expression, chromatin remodeling, and DNA repair. Dysregulation of HMGA1 is implicated in cancer progression, where its overexpression correlates with tumor aggressiveness, metastasis, and poor prognosis. The HMG4 antibody is widely used in research to detect HMGA1/2 expression via techniques like Western blotting, immunohistochemistry, and immunofluorescence. It aids in studying HMGA1's oncogenic functions, epigenetic regulation, and interactions with signaling pathways (e.g., Wnt/β-catenin, NF-κB). Additionally, it serves as a potential biomarker in diagnostic applications for cancers such as breast, colorectal, and pancreatic carcinomas. Studies also explore HMGA1's role in metabolic disorders and stem cell pluripotency, highlighting its broader biological significance. The antibody's specificity and reliability make it a critical tool in both basic and translational research contexts.

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