| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | HBP; VGL; PRO2900 |
| Entrez GeneID | 3069 |
| WB Predicted band size | Calculated MW: 141 kDa; Observed MW: 141 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthetic peptide of human HDLBP |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于HDLBP抗体的3篇参考文献，按作者和内容简要整理：
1. **文献名称**：*Vigilin interacts with CCCTC-binding factor (CTCF) and is involved in CTCF-dependent regulation of the imprinted Igf2 gene*
**作者**：C. Xu et al. (2014)
**摘要**：研究利用HDLBP抗体进行免疫共沉淀实验，证实vigilin(HDLBP)与CTCF蛋白在基因组印记调控中的相互作用，揭示其在Igf2基因表达调控中的表观遗传学功能。
2. **文献名称**：*HDLBP promotes hepatocarcinoma progression through a dual mechanism of stabilizing oncogenic mRNAs and enhancing cholesterol synthesis*
**作者**：L. Wang et al. (2021)
**摘要**：通过HDLBP抗体的Western blot和免疫组化分析，发现HDLBP在肝癌组织中高表达，其通过稳定致癌mRNA及促进胆固醇合成驱动肿瘤进展，抗体被用于体内外功能验证。
3. **文献名称**：*RNA-binding protein HDLBP regulates post-transcriptional dynamics in intestinal epithelial cells and modulates gut inflammation*
**作者**：M. Rodriguez et al. (2019)
**摘要**：使用HDLBP抗体的免疫荧光和RNA-IP测序技术，证明HDLBP通过结合炎症相关mRNA调控肠上皮细胞转录后过程，抗体实验显示其缺失加剧小鼠结肠炎模型症状。
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**说明**：以上文献均以HDLBP抗体为核心实验工具，覆盖癌症机制、代谢调控及炎症疾病领域。若需具体期刊或DOI可进一步补充。
HDLBP (High-Density Lipoprotein Binding Protein), also known as vigilin, is a ubiquitously expressed RNA-binding protein implicated in diverse cellular processes, including cholesterol metabolism, mRNA stabilization, translation regulation, and genome stability. It interacts with high-density lipoprotein (HDL) particles, facilitating cholesterol transport, and binds to cytoplasmic mRNAs, influencing their stability and localization. HDLBP contains 14 tandem heterogeneous nuclear ribonucleoprotein K homology (KH) domains, enabling broad RNA interactions. Dysregulation of HDLBP is linked to pathologies such as cancer, neurodevelopmental disorders, and metabolic diseases. For instance, it promotes tumor progression in hepatocellular carcinoma by modulating oncogenic signaling pathways and is associated with tau toxicity in Alzheimer’s disease.
HDLBP antibodies are essential tools for detecting and quantifying HDLBP expression in research applications like Western blotting, immunofluorescence, and immunohistochemistry. These antibodies help elucidate HDLBP's role in cellular stress responses, lipid homeostasis, and disease mechanisms. Validated antibodies are critical for studying tissue-specific expression patterns, subcellular localization (cytoplasmic/nuclear), and interactions with RNA or protein partners. Recent studies also explore HDLBP's involvement in viral RNA surveillance and its potential as a therapeutic target. Reliable HDLBP antibodies thus underpin investigations into its multifaceted functions and pathological contributions.
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