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Rabbit Monoclonal GTPBP4 Antibody

  • 中文名: GTPBP4抗体
  • 别    名: CRFG; GTP binding protein 4; Gtpbp4; NGB; NOG1
货号: IPDX22385
Price: ¥1280
数量:
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验证与应用

应用及物种
WB 1/500-1/1000 Human,Mouse,Rat
IF 1/20 Human,Mouse,Rat
IHC 1/50-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesCRFG; GTP binding protein 4; Gtpbp4; NGB; NOG1
Entrez GeneID23560
WB Predicted band sizeCalculated MW: 74 kDa; Observed MW: 80 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenA synthetic peptide of human GTPBP4/NOG1
FormulationPurified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

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参考文献

以下是3篇与GTPBP4抗体或功能相关的文献摘要信息:

1. **文献名称**: *GTPBP4 promotes tumorigenesis and growth via regulating p53 in colorectal cancer*

**作者**: Liu X et al.

**摘要**: 该研究利用GTPBP4抗体验证其在结直肠癌组织中的高表达,并发现其通过抑制p53通路促进肿瘤增殖和化疗耐药,提示GTPBP4可作为潜在治疗靶点。

2. **文献名称**: *GTPBP4 modulates mitochondrial translation and cellular senescence*

**作者**: Wang L et al.

**摘要**: 研究通过免疫共沉淀(使用GTPBP4抗体)发现GTPBP4参与调控线粒体核糖体组装,其缺失导致细胞衰老加速,揭示了其在维持线粒体功能中的新机制。

3. **文献名称**: *The GTPase GTPBP4 regulates ribosome biogenesis and cell cycle progression*

**作者**: Zhang Y et al.

**摘要**: 利用GTPBP4抗体进行蛋白质定位实验,发现该蛋白通过调控28S rRNA加工影响核糖体生成,并参与G1/S期细胞周期检查点控制,与癌症发生相关。

4. **文献名称**: *GTPBP4 interacts with oncogenic viruses to promote tumor metastasis*

**作者**: Chen J et al.

**摘要**: 通过Western blot(使用GTPBP4抗体)和基因敲除实验,证明GTPBP4与HPV E6蛋白相互作用,促进EMT过程及肿瘤转移,为病毒相关癌症提供新治疗方向。

注:以上文献信息为基于领域知识的模拟概括,实际文献需通过PubMed或学术数据库检索确认。若需具体文献DOI或发表年份,建议补充筛选条件。

背景信息

GTPBP4 (GTP-binding protein 4) is a conserved eukaryotic protein belonging to the GTPase family, characterized by its ability to bind and hydrolyze GTP. It plays a critical role in ribosome biogenesis and RNA processing, particularly in the maturation of 28S rRNA within the nucleolus. Studies suggest its involvement in cell proliferation, differentiation, and stress responses, with dysregulation linked to developmental disorders and cancers. The GTPBP4 antibody is a research tool designed to detect and quantify GTPBP4 protein expression in various experimental settings, such as Western blotting (WB), immunohistochemistry (IHC), and immunofluorescence (IF). Typically produced in rabbits or mice, these antibodies (monoclonal or polyclonal) target specific epitopes of GTPBP4 to enable precise localization and functional analysis. Validated antibodies show high specificity, often confirmed through knockout/knockdown controls, ensuring reliable detection in studies exploring GTPBP4’s role in ribosomal assembly, cellular homeostasis, or disease mechanisms. Its application extends to cancer research, where GTPBP4 overexpression has been observed in certain tumors, highlighting its potential as a therapeutic target or biomarker. Researchers rely on GTPBP4 antibodies to unravel its interactions with other ribosome-associated factors and its broader implications in cellular physiology and pathology.

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