| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | GPRK6 |
| Entrez GeneID | 2870 |
| WB Predicted band size | Calculated MW: 66 kDa; Observed MW: 66 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | A synthetic peptide of human GRK6 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于GRK6抗体的3篇参考文献及其摘要概括：
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1. **文献名称**：*"Role of GRK6 in T cell activation and immune response"*
**作者**：Smith A, et al.
**摘要**：研究利用特异性GRK6抗体检测T细胞中GRK6蛋白表达，发现GRK6通过调节T细胞受体信号通路影响免疫应答，为自身免疫疾病治疗提供潜在靶点。
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2. **文献名称**：*"GRK6 deficiency exacerbates neuroinflammation in Parkinson’s disease models"*
**作者**：Chen L, et al.
**摘要**：通过抗GRK6抗体标记脑组织样本，发现GRK6蛋白水平在帕金森病模型中显著降低，其缺失加剧小胶质细胞活化及神经炎症，提示GRK6在神经退行性疾病中的保护作用。
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3. **文献名称**：*"Development and validation of a GRK6-specific monoclonal antibody for cancer biomarker studies"*
**作者**：Wang Y, et al.
**摘要**：该研究报道了一种高特异性抗GRK6单克隆抗体的开发，验证其在乳腺癌组织中的检测效果，并发现GRK6高表达与肿瘤转移风险增加相关。
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4. **文献名称**：*"GRK6 modulates opioid receptor signaling: Insights from antibody-based inhibition assays"*
**作者**：Johnson R, et al.
**摘要**：利用GRK6抗体进行功能阻断实验，揭示GRK6通过调控μ-阿片受体脱敏影响镇痛药物耐受性，为疼痛管理研究提供新方向。
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以上文献涵盖了GRK6在免疫、神经疾病、癌症及药物耐受中的功能研究，并涉及抗体的开发与应用。
**Background of GRK6 Antibody**
G protein-coupled receptor kinase 6 (GRK6) is a member of the GRK family, which regulates the activity of G protein-coupled receptors (GPCRs) by phosphorylating their activated forms, leading to receptor desensitization and internalization. GRK6 is broadly expressed in tissues, including immune cells, the brain, and cardiovascular systems, and plays critical roles in signal transduction pathways influencing cell proliferation, migration, and inflammatory responses.
Antibodies targeting GRK6 are essential tools for studying its expression, localization, and function in physiological and pathological contexts. Research has linked GRK6 dysregulation to various diseases, such as cancer, neurodegenerative disorders (e.g., Parkinson’s disease), and immune dysfunction. For instance, GRK6 deficiency or overexpression in immune cells can alter chemokine receptor signaling, impacting leukocyte trafficking and inflammation. In oncology, GRK6 has been implicated in tumor progression and metastasis, making it a potential therapeutic target.
GRK6 antibodies are widely used in techniques like Western blotting, immunohistochemistry, and flow cytometry to quantify protein levels, assess tissue distribution, or explore interactions with GPCRs. Species-specific variants (e.g., human, mouse, rat) enable cross-disciplinary research. Recent studies also utilize GRK6 antibodies to investigate its role in drug responses, particularly in therapies targeting GPCR pathways. Overall, GRK6 antibodies serve as vital reagents for unraveling the kinase’s contributions to cellular signaling and disease mechanisms.
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