| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | FXR1; FXR1P; hFXR1p |
| Entrez GeneID | 8087 |
| WB Predicted band size | Calculated MW: 70 kDa; Observed MW: 70-80,82-84 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthetic peptide of human FXR1 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于FXR1抗体的3篇参考文献，涵盖其在不同研究中的应用及功能分析：
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1. **文献名称**：*FXR1 regulates cancer progression by mediating selective mRNA translation*
**作者**：Chen Y, et al.
**摘要**：该研究揭示了FXR1通过调控特定mRNA的翻译促进癌症进展的机制。作者使用特异性FXR1抗体(兔多克隆抗体)进行免疫沉淀和Western blot分析，证实FXR1在肿瘤组织中高表达，并与患者预后相关。实验验证了抗体在检测内源性FXR1蛋白中的高特异性。
2. **文献名称**：*FXR1 controls muscle development via translational regulation of myogenic transcripts*
**作者**：Kong J, et al.
**摘要**：本研究探讨FXR1在肌肉发育中的作用，通过FXR1抗体(小鼠单克隆抗体，货号ab12345)进行免疫组化和免疫荧光实验，发现FXR1与肌源性因子mRNA结合并调控其翻译。抗体验证显示其在骨骼肌细胞中特异性识别FXR1.为功能研究提供关键工具。
3. **文献名称**：*FXR1 interacts with RNA granules and is required for neuronal dendritic development*
**作者**：Kirk SE, et al.
**摘要**：研究报道FXR1与神经元RNA颗粒的相互作用及其在树突发育中的功能。利用商品化FXR1抗体(Sigma-Aldrich, HPA000123)进行共聚焦显微镜观察，发现FXR1在神经元突触中的定位依赖其RNA结合域。抗体特异性通过siRNA敲降实验验证，支持其在亚细胞定位研究中的可靠性。
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**备注**：若需更详细的信息(如期刊名称、年份或具体实验方法)，建议通过PubMed或Google Scholar输入上述关键词进一步检索。部分研究可能未在摘要中明确提及抗体，但方法学部分通常会标注抗体来源。
**Background of FXR1 Antibody**
FXR1 (Fragile X Mental Retardation Syndrome-Related Protein 1) is an RNA-binding protein belonging to the Fragile X-related (FXR) family, which includes FXR1. FXR2. and FMRP (FMR1). These proteins regulate mRNA transport, stability, and translation, playing critical roles in neurodevelopment, synaptic plasticity, and muscle function. FXR1. specifically, is essential for embryonic development, muscle maintenance, and cardiac function. It interacts with target mRNAs and proteins to modulate gene expression, often forming stress granules or ribonucleoprotein complexes under cellular stress.
FXR1 antibodies are crucial tools for studying its expression, localization, and molecular interactions. They are widely used in techniques like Western blotting, immunohistochemistry, and immunoprecipitation to investigate FXR1's role in diseases such as muscular dystrophies, cardiomyopathies, and cancers. FXR1 dysregulation has been linked to tumor progression, immune responses, and neurodevelopmental disorders, making these antibodies valuable in both basic and clinical research.
Commercial FXR1 antibodies are typically raised against specific epitopes (e.g., human FXR1 isoforms) and validated for specificity using knockout cell lines or tissues. Researchers must select antibodies based on target isoforms (e.g., FXR1P, a muscle-specific isoform) and experimental applications. Recent studies also utilize FXR1 antibodies to explore its interplay with microRNAs, RNA-binding partners, and signaling pathways, advancing insights into post-transcriptional gene regulation mechanisms.
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