| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | EPS15R |
| Entrez GeneID | 58513 |
| WB Predicted band size | Calculated MW: 94 kDa; Observed MW: 130 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthetic peptide of human EPS15R |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于EPS15R抗体的虚构参考文献示例(仅供格式参考，实际文献需查询数据库)：
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1. **文献名称**: "Characterization of EPS15R Antibody in Clathrin-Mediated Endocytosis"
**作者**: Müller A, et al.
**摘要**: 本研究利用新型EPS15R抗体验证了其在网格蛋白介导的内吞作用中的定位，发现EPS15R与EGFR信号通路的动态调控相关，抗体特异性通过敲除实验验证。
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2. **文献名称**: "EPS15R as a Biomarker in Triple-Negative Breast Cancer"
**作者**: Chen L, et al.
**摘要**: 通过EPS15R抗体免疫组化分析，发现EPS15R在三阴性乳腺癌组织中高表达，并与患者预后不良相关，提示其可能成为潜在治疗靶点。
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3. **文献名称**: "EPS15R Antibody Reveals Altered Synaptic Vesicle Recycling in Neurons"
**作者**: Park S, et al.
**摘要**: 使用EPS15R抗体标记发现，神经元突触小泡循环中EPS15R与AP2复合物相互作用，其缺失导致神经递质释放异常，提示其在神经退行性疾病中的作用。
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4. **文献名称**: "Development of a Monoclonal EPS15R Antibody for Therapeutic Targeting"
**作者**: Rossi G, et al.
**摘要**: 报道了一种高亲和力EPS15R单克隆抗体的开发，体外实验显示其可抑制肿瘤细胞迁移和侵袭，为靶向癌症转移提供了新策略。
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**注意**：以上内容为模拟示例，实际文献需通过PubMed/Google Scholar等平台检索关键词(如"EPS15R antibody"、"EPS15R function")。
The EPS15R (Epidermal Growth Factor Receptor Pathway Substrate 15-Related) antibody targets the EPS15R protein, a member of the EPS15 homology (EH) domain-containing protein family. EPS15R, also known as EPS15L1. shares structural homology with EPS15. including N-terminal tandem EH domains and a C-terminal coiled-coil region. These domains facilitate protein-protein interactions critical for clathrin-mediated endocytosis and receptor tyrosine kinase (RTK) signaling, particularly EGFR trafficking and downstream signal modulation.
EPS15R is implicated in regulating intracellular vesicle transport, membrane receptor internalization, and signal transduction. Dysregulation of EPS15R has been linked to cancer progression, metastasis, and therapeutic resistance, especially in tumors with aberrant RTK activity (e.g., lung, breast cancers). The EPS15R antibody is widely used in research to study these mechanisms via techniques like Western blotting, immunofluorescence, and immunoprecipitation. It helps assess EPS15R expression patterns, subcellular localization, and interactions with partners like clathrin, adaptor proteins, and ubiquitin ligases.
Commercial EPS15R antibodies are typically validated for specificity in human, mouse, or rat samples, with applications in cancer biology, neurobiology (due to synaptic vesicle recycling roles), and drug discovery. Researchers prioritize antibodies with robust validation (e.g., knockout controls) to ensure accuracy in mechanistic studies exploring EPS15R’s dual roles in homeostasis and disease.
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