| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | CTH; Cystathionine gamma lyase; Cysteine desulfhydrase; Gamma cystathionase; Homoserine deaminase |
| Entrez GeneID | 1491 |
| WB Predicted band size | Calculated MW: 45 kDa; Observed MW: 45 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthetic peptide of human Cystathionase/CTH |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是3篇与Cystathionase(胱硫醚酶，CSE)抗体相关的参考文献示例(内容为模拟概括，非真实文献)：
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1. **文献名称**：*Development and Characterization of a Monoclonal Antibody for Human Cystathionine Gamma-Lyase*
**作者**：Smith A, et al.
**摘要**：本研究开发了一种针对人源胱硫醚酶(CSE)的高特异性单克隆抗体，验证了其在Western blot和免疫组化中的应用。实验证明该抗体可有效检测多种组织(如肝脏、血管内皮)中的CSE蛋白表达，并用于研究CSE在硫化氢(H₂S)代谢中的调控机制。
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2. **文献名称**：*Cystathionine Gamma-Lyase Deficiency in Cardiovascular Disease: Insights from Immunohistochemical Analysis*
**作者**：Chen L, et al.
**摘要**：通过使用CSE特异性抗体，作者发现心血管疾病患者血管组织中CSE蛋白表达显著降低，提示CSE功能缺陷可能与内皮功能障碍相关。抗体在组织切片中的定位显示CSE主要分布于平滑肌细胞和巨噬细胞。
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3. **文献名称**：*Role of Cystathionase in Liver Injury: Antibody-Based Proteomic Profiling*
**作者**：Yamamoto K, et al.
**摘要**：利用CSE抗体进行蛋白质组学分析，揭示了CSE在肝损伤模型中的动态变化。研究指出，CSE表达上调可能通过调节氧化应激减轻肝脏纤维化，抗体检测结果为靶向治疗提供了分子依据。
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4. **文献名称**：*Antibody Validation for CSE in Cancer Cell Lines*
**作者**：Wang X, et al.
**摘要**：该研究系统验证了多种商业CSE抗体的特异性，发现部分抗体存在交叉反应。通过CRISPR敲除实验确认了可靠抗体，并应用于乳腺癌细胞系中CSE表达与化疗耐药性的相关性分析。
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(注：以上文献为示例性内容，实际引用时需查询真实数据库如PubMed。)
Cystathionase, also known as cystathionine γ-lyase (CSE), is a key enzyme in the transsulfuration pathway, catalyzing the conversion of cystathionine to cysteine, α-ketobutyrate, and ammonia. This enzyme plays a critical role in sulfur-containing amino acid metabolism and hydrogen sulfide (H₂S) biosynthesis, a gaseous signaling molecule involved in vascular regulation, anti-inflammatory responses, and oxidative stress modulation. CSE is highly expressed in tissues such as the liver, kidney, and vasculature, and its dysregulation has been linked to cardiovascular diseases, diabetes, and neurodegenerative disorders.
Cystathionase-specific antibodies are essential tools for studying the expression, localization, and function of this enzyme in both physiological and pathological contexts. These antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence to quantify CSE protein levels or visualize its tissue distribution. Researchers also employ them to investigate CSE's role in H₂S-mediated signaling pathways and its interaction with other metabolic regulators. Commercially available antibodies are typically raised against conserved epitopes of human or murine CSE, with validation across species and applications. Recent studies using these antibodies have highlighted CSE's potential as a therapeutic target, particularly in conditions associated with H₂S deficiency or oxidative damage. Robust antibody specificity remains crucial, given structural similarities between CSE and related enzymes like cystathionine β-synthase (CBS).
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