| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | MPS2; SIDS |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human IDS |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于Chromogranin A抗体的3篇参考文献示例(均为虚构内容，仅作格式参考)：
1. **文献名称**: *Chromogranin A as a universal biomarker for neuroendocrine tumors: Antibody validation and clinical utility*
**作者**: Lloyd RV, et al.
**摘要**: 研究验证了多种CgA抗体的特异性，发现单克隆抗体Clone LK2H10在免疫组化中对神经内分泌肿瘤(如胰腺癌、类癌)的诊断敏感性和特异性最高，优于其他商业化抗体。
2. **文献名称**: *Comparative analysis of Chromogranin A antibodies in ELISA assays: Impact on diagnostic accuracy*
**作者**: Portela-Gomes GM, et al.
**摘要**: 比较了三种CgA抗体(包括多克隆和单克隆抗体)在ELISA检测中的性能，发现多克隆抗体在检测血清CgA时灵敏度更高，但单克隆抗体在区分肿瘤分期中特异性更优。
3. **文献名称**: *Chromogranin A antibody cross-reactivity with other granins: Implications for pathology interpretation*
**作者**: D’Ambrogi F, et al.
**摘要**: 揭示了部分CgA抗体可能与Chromogranin B或Secretogranin发生交叉反应，建议结合多种抗体标记以减少神经内分泌肿瘤诊断中的假阳性结果。
注：以上文献信息为模拟示例，实际引用需查询真实数据库(如PubMed)。
Chromogranin A (CgA) antibodies are essential tools in identifying and studying neuroendocrine cells and their associated tumors. Chromogranin A, a 48 kDa acidic protein, is a member of the granin family of secretory glycoproteins stored in dense-core vesicles of neuroendocrine cells, including neurons, endocrine cells, and neuroendocrine tumor cells. It plays a role in granulogenesis, hormone packaging, and regulating secretion. CgA is co-released with hormones like catecholamines, insulin, and gastrin, making it a universal biomarker for neuroendocrine differentiation.
CgA antibodies are widely used in immunohistochemistry (IHC) to detect neuroendocrine tumors (NETs), such as pheochromocytomas, paragangliomas, carcinoids, and pancreatic NETs. They help differentiate NETs from non-neuroendocrine neoplasms. In research, these antibodies aid in studying secretory pathways and neuroendocrine system dysregulation. Commercially available CgA antibodies are typically monoclonal or polyclonal, targeting specific epitopes, often in the conserved N-terminal region. Validation ensures specificity for diagnostic accuracy.
Beyond oncology, CgA levels (measured via ELISA or radioimmunoassay) correlate with tumor burden, treatment response, and prognosis. However, false elevations may occur due to proton pump inhibitor use, renal insufficiency, or chronic inflammation. Despite limitations, CgA remains a cornerstone in neuroendocrine biomarker studies, underscoring the antibody's diagnostic and research significance.
×
