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Rabbit Monoclonal CCT2 Antibody

  • 中文名: CCT2抗体
  • 别    名: CCT2; 99D8.1; CCTB; T-complex protein 1 subunit beta; TCP-1-beta; CCT-beta
货号: IPDX22290
Price: ¥1280
数量:
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验证与应用

应用及物种
WB 1/500-1/1000 Human,Mouse,Rat
IF 1/20 Human,Mouse,Rat
IHC 1/50-1/100 Human,Mouse,Rat
ICC 1/50-1/200 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesCCT2; 99D8.1; CCTB; T-complex protein 1 subunit beta; TCP-1-beta; CCT-beta
Entrez GeneID10576
WB Predicted band sizeCalculated MW: 57 kDa; Observed MW: 57 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthetic peptide of human CCT2
FormulationPurified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

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参考文献

以下是关于CCT2抗体的3篇参考文献及其摘要概括:

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1. **文献名称**: *CCT2 is an aggresome formation regulator modulating pancreatic carcinogenesis*

**作者**: Chen Y, et al.

**摘要**: 研究利用CCT2特异性抗体,发现CCT2通过调控异常蛋白聚集体的形成促进胰腺癌细胞增殖和转移,提示其作为治疗靶点的潜力。

2. **文献名称**: *Targeting CCT2 by its inhibitor AC-3265 for the treatment of triple-negative breast cancer*

**作者**: Zhang L, et al.

**摘要**: 通过CCT2抗体验证AC-3265抑制剂对CCT2蛋白的靶向作用,证明其可抑制三阴性乳腺癌细胞的生长并诱导凋亡。

3. **文献名称**: *CCT2 interacts with β-catenin to drive stemness in colorectal cancer*

**作者**: Wang H, et al.

**摘要**: 采用CCT2抗体进行免疫共沉淀实验,揭示CCT2与β-catenin互作维持结直肠癌干性,为抗体阻断治疗策略提供依据。

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**说明**:以上文献均为虚拟示例,实际研究中建议通过PubMed或Web of Science检索关键词“CCT2 antibody”或“CCT2 inhibitor”获取真实文献。

背景信息

The CCT2 antibody is a research tool targeting the Chaperonin Containing TCP1 subunit 2 (CCT2), a critical component of the eukaryotic chaperonin complex CCT (also known as TRiC). This complex facilitates ATP-dependent folding of nascent polypeptides, particularly cytoskeletal proteins like actin and tubulin, ensuring proper structural and functional maturation. CCT2. as one of eight homologous subunits (CCT1-8), forms a double-ring structure that binds unfolded proteins in a closed conformation, undergoing ATP hydrolysis to drive folding. Dysregulation of CCT2 is implicated in cancer, neurodegenerative diseases, and developmental disorders due to its role in maintaining proteostasis. The CCT2 antibody is widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to study protein expression, localization, and interactions. It helps investigate CCT2's involvement in cellular processes such as cell cycle regulation, stress responses, and tumor progression. Recent studies highlight its potential as a biomarker in cancers, where overexpression correlates with metastasis and poor prognosis. Researchers also explore its therapeutic relevance, as CCT2 inhibition may disrupt oncogenic pathways. Validation of antibody specificity remains essential, given structural similarities among CCT subunits. Overall, the CCT2 antibody serves as a vital reagent for probing proteostasis mechanisms and disease pathogenesis.

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