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Rabbit Monoclonal CBX4 Antibody

  • 中文名： CBX4抗体
  • 别    名： CBX4; hPc2; NBP16; PC2
货号: IPDX22289
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 1/500-1/1000 Human,Mouse,Rat
IF 1/20 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesCBX4; hPc2; NBP16; PC2
Entrez GeneID8535
WB Predicted band sizeCalculated MW: 61 kDa; Observed MW: 61 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthetic peptide of human CBX4
FormulationPurified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

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参考文献

以下是3篇与CBX4抗体相关的文献示例(内容基于公开研究整理，非真实文献)：

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1. **文献名称**: "CBX4 modulates hepatocellular carcinoma progression via HDAC1-mediated epigenetic regulation"

**作者**: Zhang, Y. et al. (2018)

**摘要**: 本研究通过Western blot和免疫组化(使用兔源CBX4多克隆抗体)发现CBX4在肝癌组织中高表达，且与患者不良预后相关。实验表明CBX4通过招募HDAC1抑制肿瘤抑制基因表达，促进癌细胞增殖和转移。

2. **文献名称**: "CBX4 maintains stem cell senescence through SUMOylation of TERF2"

**作者**: Liu, X. et al. (2020)

**摘要**: 该研究利用CBX4特异性抗体(货号ab12345.ABC公司)进行免疫荧光染色和ChIP实验，发现CBX4通过SUMO化修饰端粒相关蛋白TERF2.维持间充质干细胞的衰老表型，为抗衰老治疗提供潜在靶点。

3. **文献名称**: "CBX4 mediates DNA repair by regulating homologous recombination"

**作者**: Li, H. et al. (2017)

**摘要**: 通过siRNA敲低结合CBX4抗体(小鼠单克隆抗体，克隆号3B8)的验证实验，研究发现CBX4通过招募RAD51至DNA损伤位点促进同源重组修复，缺失CBX4会导致基因组不稳定性增加。

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**注**: 实际文献检索建议通过PubMed或Google Scholar以“CBX4 antibody”及研究领域(如癌症、表观遗传)为关键词筛选。部分抗体可能标注于方法学部分而非标题/摘要中。

背景信息

The CBX4 antibody is a research tool designed to detect and study the Chromobox homolog 4 (CBX4) protein, a member of the Polycomb Repressive Complex 1 (PRC1) family. CBX4. also known as Pc2. is a chromodomain-containing protein involved in epigenetic regulation, particularly in mediating gene silencing through histone modification. It plays a critical role in maintaining cellular identity, differentiation, and proliferation by facilitating H2A ubiquitination and chromatin compaction. CBX4 is unique among Polycomb group proteins for its dual functionality, acting both as a transcriptional repressor and a SUMO E3 ligase, which enables post-translational modification of target proteins to influence processes like DNA repair, stress response, and senescence. Dysregulation of CBX4 has been implicated in cancers, neurodegenerative diseases, and aging-related pathologies. The CBX4 antibody is widely used in techniques such as Western blotting, immunofluorescence, chromatin immunoprecipitation (ChIP), and immunohistochemistry to investigate its expression patterns, subcellular localization, and interactions with other biomolecules. Researchers rely on validated CBX4 antibodies to explore its role in epigenetic mechanisms and therapeutic targeting. Commercial antibodies are typically raised against specific epitopes, with host species (e.g., rabbit, mouse) and clonality (monoclonal/polyclonal) varying across suppliers. Proper validation via knockout controls or siRNA knockdown is essential to ensure specificity in experimental models.

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