| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | MO25; CGI-66 |
| Entrez GeneID | 51719 |
| WB Predicted band size | Calculated MW: 40 kDa; Observed MW: 40 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthetic peptide of human CAB39/MO25 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是3篇与CAB39抗体相关的文献摘要信息，供参考：
1. **文献名称**：CAB39 interacts with LKB1 to regulate cell proliferation and metastasis in lung cancer
**作者**：Li X, et al.
**摘要**：研究通过免疫共沉淀和Western blot技术，使用CAB39抗体验证其在非小细胞肺癌中与LKB1的相互作用，揭示CAB39-LKB1轴通过抑制mTOR信号通路调控肿瘤转移的机制。
2. **文献名称**：Calcium-binding protein 39 promotes hepatocellular carcinoma growth through autophagy induction
**作者**：Wang Y, et al.
**摘要**：利用CAB39特异性抗体进行免疫组化分析，发现CAB39在肝癌组织中高表达，并通过激活自噬相关蛋白LC3促进肿瘤细胞增殖，提示其作为潜在治疗靶点。
3. **文献名称**：STRADα-CAB39 complex regulates polarity and energy metabolism in colorectal cancer
**作者**：Sanchez-Cespedes M, et al.
**摘要**：研究通过shRNA敲低结合CAB39抗体的免疫荧光技术，证明CAB39与STRADα协同调控结直肠癌细胞极性及糖酵解代谢重编程，影响肿瘤微环境适应。
注：以上文献为模拟摘要，实际引用需根据PubMed或学术数据库检索具体论文。建议以“CAB39 antibody”、“MO25/LKB1 complex”等关键词在NCBI/Google Scholar筛选实验验证类文章。
The CAB39 (Calcium-binding protein 39) antibody is a tool used to detect the CAB39 protein, a key component of the serine/threonine kinase LKB1-STRAD-CAB39 complex. This complex regulates cellular energy metabolism and polarity by activating AMP-activated protein kinase (AMPK) and other downstream targets. CAB39. also known as MO25. stabilizes the interaction between LKB1 (a tumor suppressor kinase) and STRAD (STE20-related adapter), facilitating LKB1’s translocation to the cytoplasm and its kinase activity.
CAB39 is implicated in various physiological processes, including cell proliferation, apoptosis, and stress response. Dysregulation of CAB39 has been linked to cancers (e.g., hepatocellular carcinoma, colorectal cancer) and metabolic disorders. Antibodies targeting CAB39 are essential for studying its expression, localization, and interactions in these contexts. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to explore CAB39’s role in disease mechanisms or signaling pathways. Research using CAB39 antibodies has highlighted its potential as a biomarker or therapeutic target, particularly in oncology and metabolic syndrome studies. Commercial CAB39 antibodies are typically validated for specificity across human and model organism samples.
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