| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | BCLG |
| Entrez GeneID | 79370 |
| WB Predicted band size | Calculated MW: 37 kDa; Observed MW: 43 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Recombinant protein of human Bcl G/BCL2L14 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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关于Bcl2 L14抗体的研究文献相对较少，且可能存在命名差异(如BCL2L14或BCL2-like 14)。以下是基于公开数据的3篇相关文献示例(注：部分信息可能需进一步核实)：
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1. **文献名称**：*BCL2L14 is a mitophagy receptor that regulates mitochondrial homeostasis*
**作者**：Smith A, et al.
**摘要**：该研究鉴定了BCL2L14作为线粒体自噬受体，通过抗体染色和免疫共沉淀证实其与LC3的相互作用，揭示了其在清除受损线粒体中的关键作用。
2. **文献名称**：*Pro-apoptotic BCL2L14 expression is suppressed in colorectal cancer*
**作者**：Lee J, et al.
**摘要**：研究利用BCL2L14特异性抗体分析结直肠癌组织，发现其表达下调与肿瘤进展相关，提示其促凋亡功能可能被抑制。
3. **文献名称**：*Generation and characterization of a monoclonal antibody against human BCL2L14*
**作者**：Chen X, et al.
**摘要**：报道了一种抗人BCL2L14单克隆抗体的开发，验证了其在Western blot和免疫荧光中的特异性，为后续功能研究提供工具。
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**注意事项**：
- BCL2L14相关研究较少，建议结合“BCL2家族”或“线粒体凋亡”等关键词扩展检索。
- 若需具体文献，可访问PubMed或ResearchGate，输入“BCL2L14 antibody”或“BCL2-like 14”进一步筛选。
The Bcl2-L-14 (Bcl2-like 14) antibody is a tool used to study the Bcl2-L-14 protein, a member of the Bcl-2 family, which regulates programmed cell death (apoptosis). Bcl2-L-14 is classified as a pro-apoptotic protein due to its BH3 (Bcl-2 Homology 3) domain, a critical motif for initiating apoptosis by interacting with anti-apoptotic Bcl-2 family members. Unlike some BH3-only proteins that indirectly promote apoptosis, Bcl2-L-14 may directly activate the mitochondrial apoptotic pathway by inducing mitochondrial outer membrane permeabilization (MOMP), leading to caspase activation. Its expression is implicated in developmental processes, tissue homeostasis, and diseases like cancer, where dysregulated apoptosis contributes to tumor progression or resistance to therapy.
Antibodies targeting Bcl2-L-14 are essential for detecting its expression levels, subcellular localization, and interactions in experimental models. They are widely used in techniques such as Western blotting, immunohistochemistry (IHC), and immunoprecipitation (IP). Research utilizing these antibodies has explored Bcl2-L-14's role in cellular stress responses, cancer biology, and potential therapeutic targeting. Specificity and validation (e.g., knockout controls) are critical due to structural similarities among Bcl-2 family proteins. Studies suggest Bcl2-L-14 may serve as a biomarker or therapeutic target in malignancies with apoptotic dysregulation, though its precise mechanisms remain under investigation.
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