关键信息
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基因名
GNaS1
- 应用
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别名
NESP55; NESP; GNASXL; GPSA; SCG6; Secretogranin VI; Adenylate cyclase-stimulating G alpha protein; Guanine Nucleotide Binding Protein Alpha Stimulating Activity Polypeptide 1
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P63092
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表达区间
Gly2~Leu380
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分子量
49kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
GNaS1, or the guanine nucleotide-binding protein, alpha stimulating 1, plays a crucial role in various cellular signaling pathways, particularly in the regulation of adenylate cyclase, which catalyzes the conversion of ATP to cyclic AMP. This process is vital for numerous physiological functions, including hormone signaling, neurotransmission, and metabolic regulation. Abnormalities in GNaS1 function have been implicated in several diseases, such as congenital hyperinsulinism and certain endocrine tumors. As a result, understanding the structure and function of GNaS1 is essential for elucidating its role in health and disease. Research into the recombinant expression of GNaS1 protein allows scientists to obtain large quantities of pure protein for biochemical and biophysical studies, enabling detailed analysis of its interactions with receptors and effectors in signaling pathways. Moreover, characterizing GNaS1's structure can provide insights into its mechanism of action and potential therapeutic targets. Advances in recombinant DNA technology have facilitated the production of GNaS1 in various expression systems, paving the way for more in-depth investigations into its biological functions and the development of novel interventions for related disorders. This research is not only fundamental for basic science but also holds translational potential in the context of drug development and precision medicine.
