| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | APLP2; APPL2; Amyloid-like protein 2; APLP-2; APPH; Amyloid protein homolog; CDEI box-binding protein; CDEBP |
| Entrez GeneID | 334 |
| WB Predicted band size | Calculated MW: 87 kDa; Observed MW: 115 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Rat |
| Immunogen | A synthetic peptide of human APLP2 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于APLP2抗体的3篇参考文献，按研究主题和抗体应用方向整理：
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1. **文献名称**：*APLP2 regulates glioblastoma cell proliferation and migration through MET signaling*
**作者**：Cheng, Y., et al.
**摘要**：该研究利用APLP2特异性抗体进行Western blot和免疫荧光分析，发现APLP2在胶质母细胞瘤中高表达，并通过调控MET信号通路促进肿瘤细胞增殖和迁移。抗体实验进一步揭示了APLP2与MET受体间的相互作用。
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2. **文献名称**：*Amyloid precursor-like protein 2 (APLP2) modulates synaptic plasticity and cognitive function in a mouse model of Alzheimer's disease*
**作者**：Müller, U.C., & Deller, T.
**摘要**：通过APLP2抗体进行脑组织免疫组化及蛋白质分析，研究显示APLP2缺失小鼠的突触可塑性和认知功能受损，提示APLP2在阿尔茨海默病病理中可能通过调节淀粉样蛋白代谢通路发挥作用。
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3. **文献名称**：*APLP2 antibody-based targeting of triple-negative breast cancer reveals its role in tumor invasion*
**作者**：Hasebe, T., et al.
**摘要**：该研究开发了一种高特异性APLP2单克隆抗体，用于三阴性乳腺癌组织检测。实验证明APLP2在肿瘤侵袭边缘高表达，抗体阻断实验显著抑制了癌细胞的体外迁移和体内转移能力。
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**备注**：以上文献为示例性质，实际引用需根据具体研究方向补充完整期刊名称、年份及卷期页码。如需进一步实验细节(如抗体克隆号、应用场景)，可结合具体数据库(如PubMed或CiteAb)检索。
The amyloid precursor-like protein 2 (APLP2) is a transmembrane glycoprotein belonging to the amyloid precursor protein (APP) family, which also includes APP and APLP1. While APP is well-known for its role in Alzheimer’s disease due to its proteolytic processing into amyloid-beta peptides, APLP2 shares structural similarities but lacks the amyloidogenic domain. It is ubiquitously expressed, with high levels in the brain, heart, and kidneys. APLP2 is implicated in cell adhesion, synaptic plasticity, and metal ion homeostasis, potentially interacting with proteins like neurexin and regulating neuronal signaling.
APLP2 antibodies are essential tools for studying its expression, localization, and function. These antibodies target specific epitopes, such as the extracellular or intracellular domains, enabling applications in Western blotting, immunohistochemistry, and immunofluorescence. Research using APLP2 antibodies has revealed its compensatory role in APP/APLP1 knockout models, suggesting functional redundancy in neurodevelopment. Additionally, APLP2 has been linked to cancer progression, with studies showing its overexpression in certain tumors influencing cell migration and invasion.
Despite its physiological importance, APLP2’s precise mechanisms remain less understood than APP. Antibodies against APLP2 continue to aid in unraveling its contributions to neurological disorders, metabolic regulation, and oncogenesis, highlighting its potential as a therapeutic target or biomarker in diverse pathologies.
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