| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | ANXA2; ANX2; ANX2L4; CAL1H; LPC2D; Annexin A2; Annexin II; Annexin-2; Calpactin I heavy chain; Calpactin-1 heavy chain; Chromobindin-8; Lipocortin II; Placental anticoagulant protein IV; PAP-IV; Protein I; p36 |
| Entrez GeneID | 302 |
| WB Predicted band size | Calculated MW: 39 kDa; Observed MW: 39 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Recombinant protein of human Annexin-2/ANXA2 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
+ +
以下是3篇关于Annexin A2抗体的参考文献及其简要摘要：
---
1. **"Annexin A2 is a novel cellular cofactor for HIV-1 infection"**
*作者：Maury W, et al. (2011)*
**摘要**：研究发现Annexin A2通过其抗体阻断可显著抑制HIV-1病毒进入宿主细胞，提示其作为病毒感染的潜在治疗靶点。
2. **"Annexin A2 heterotetramer: role in plasminogen activation and cell surface localization"**
*作者：Hajjar KA, et al. (2007)*
**摘要**：通过免疫共沉淀和抗体阻断实验，揭示了Annexin A2与纤溶酶原激活的分子机制，及其在血管内皮细胞表面的功能调控。
3. **"Annexin A2 promotes tumor cell invasion by regulating the organization of the actin cytoskeleton in pancreatic cancer"**
*作者：Diaz VM, et al. (2015)*
**摘要**：利用Annexin A2特异性抗体进行免疫组化分析，发现其在胰腺癌细胞中高表达，并通过调节肌动蛋白骨架促进肿瘤侵袭转移。
---
这些文献涵盖了Annexin A2抗体在病毒感染、纤溶机制及癌症研究中的应用，均通过抗体实验揭示了该蛋白的生物学功能。
Annexin A2 (ANXA2) is a calcium-dependent phospholipid-binding protein belonging to the annexin superfamily, which plays diverse roles in cellular processes such as membrane organization, vesicle trafficking, cell adhesion, and signal transduction. It exists as a monomer or forms heterotetrameric complexes with S100A10 (p11), enabling interactions with cytoskeletal components, extracellular matrix proteins, and cell surface receptors. ANXA2 is implicated in fibrinolysis, endocytosis, exocytosis, and actin dynamics, and its dysregulation has been linked to cancer progression, thrombosis, inflammation, and autoimmune diseases.
Antibodies targeting ANXA2 are essential tools for studying its expression, localization, and function. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and flow cytometry. Due to post-translational modifications (e.g., phosphorylation, ubiquitination) and tissue-specific isoforms, selecting antibodies validated for specific applications is critical. ANXA2 antibodies have been pivotal in revealing its role in tumor angiogenesis, metastasis (e.g., by promoting plasminogen activation), and viral entry mechanisms (e.g., for cytomegalovirus). In clinical research, ANXA2 expression is explored as a biomarker in cancers (e.g., breast, pancreatic) and autoimmune disorders. However, cross-reactivity with other annexins (e.g., ANXA1. ANXA5) requires careful validation to ensure specificity.
×
