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Rabbit Monoclonal NUP62CL Antibody

  • 中文名： NUP62CL抗体
  • 别    名： NUP62L; Nucleoporin-62 C-terminal-like protein
货号: IPDX22228
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 1/500-1/1000 Human,Mouse,Rat
IF 1/20 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesNUP62L; Nucleoporin-62 C-terminal-like protein
Entrez GeneID54830
WB Predicted band sizeCalculated MW: 21 kDa; Observed MW: 21 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenA synthetic peptide of human NUP62CL
FormulationPurified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

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参考文献

以下是关于NUP62CL抗体的假设性参考文献示例(基于领域知识推测，非真实文献)：

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1. **文献名称**: *NUP62CL Antibody Characterization in Autism Spectrum Disorder Models*

**作者**: Smith A, et al.

**摘要**: 本研究验证了NUP62CL抗体在自闭症谱系障碍(ASD)患者细胞模型中的特异性，发现NUP62CL蛋白在神经元核膜定位异常可能与ASD相关。抗体通过免疫荧光和Western blot确认其结合靶点。

2. **文献名称**: *Role of NUP62CL in Nuclear Pore Complex Assembly*

**作者**: Tanaka K, et al.

**摘要**: 利用NUP62CL抗体探究其在核孔复合体(NPC)组装中的作用，发现NUP62CL缺失导致核质运输障碍，抗体染色显示其与NUP62存在共定位，提示功能协同性。

3. **文献名称**: *Development of a Novel Monoclonal Antibody Against NUP62CL for Cancer Research*

**作者**: Lee H, et al.

**摘要**: 报道一种新型NUP62CL单克隆抗体的开发，通过免疫组化验证其在多种癌症组织中的表达差异，提示NUP62CL可能作为肿瘤生物标志物。

4. **文献名称**: *NUP62CL Mutations and Cellular Localization in Developmental Disorders*

**作者**: García-Rojas M, et al.

**摘要**: 研究NUP62CL基因突变对蛋白亚细胞定位的影响，使用特异性抗体揭示突变导致核膜分布异常，可能与神经发育疾病相关。

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**说明**：以上文献为模拟示例，实际研究中可能需通过PubMed、Web of Science等平台以“NUP62CL antibody”或相关关键词检索最新成果。若研究较新或小众，建议结合抗体生产商(如Santa Cruz、Abcam)提供的说明书引用应用案例。

背景信息

The NUP62CL antibody targets NUP62 C-terminal-like protein, a component of the nuclear pore complex (NPC) implicated in nucleocytoplasmic transport. NUP62CL shares homology with the C-terminal region of nucleoporin NUP62 but is encoded by a distinct gene, potentially reflecting functional divergence or tissue-specific roles. It localizes to the nuclear membrane and interacts with other nucleoporins to regulate molecular trafficking between the nucleus and cytoplasm. Studies suggest its involvement in cellular processes such as gene expression, cell cycle regulation, and viral infection responses. NUP62CL antibodies are essential tools for investigating NPC architecture, transport mechanisms, and dysregulation in diseases like cancer or neurodegenerative disorders. Researchers use these antibodies in techniques like immunofluorescence, Western blotting, or immunoprecipitation to study protein expression, localization, and interaction networks. Recent interest has emerged in exploring NUP62CL's potential role in ciliopathies and neurodevelopmental conditions, given links between NPC dysfunction and these pathologies. Commercial availability of NUP62CL antibodies supports both basic research and clinical studies aiming to decipher its precise biological functions and therapeutic relevance.

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