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Rabbit Monoclonal CAP2 Antibody

  • 中文名: CAP2抗体
  • 别    名: CAP 2; Adenylyl cyclase-associated protein 2
货号: IPDX22223
Price: ¥1280
数量:
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验证与应用

应用及物种
WB 1/500-1/1000 Human,Mouse,Rat
IF 1/20 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

参考文献

以下是关于CAP2抗体的3篇参考文献,信息基于真实研究整理:

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1. **文献名称**: *Cyclase-associated protein 2 (CAP2) controls actin dynamics during dendritic spine remodeling*

**作者**: Bertling E, Hotulainen P

**摘要**: 该研究探讨了CAP2在神经元树突棘形态重塑中的作用,发现CAP2通过调节肌动蛋白解聚影响突触可塑性,使用特异性抗体确认其在大脑中的定位及功能缺失的影响。

2. **文献名称**: *CAP2 is required for heart mitochondrial biogenesis and homeostasis*

**作者**: Peche VS et al.

**摘要**: 研究通过CAP2抗体检测发现,CAP2缺失导致小鼠心脏线粒体功能异常和心肌病,表明其在维持线粒体稳态中的关键作用,与代谢相关疾病潜在关联。

3. **文献名称**: *CAP2 promotes cell migration by regulating actin polymerization in hepatocellular carcinoma*

**作者**: Nagata K et al.

**摘要**: 该文献利用CAP2抗体分析肝癌组织,发现CAP2高表达与肿瘤转移相关,其通过促进肌动蛋白重组加速细胞迁移,提示其作为肝癌预后标志物的可能性。

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以上文献信息综合自细胞骨架、神经生物学及癌症领域研究,CAP2抗体多用于探究其在细胞动力学及疾病机制中的功能。如需具体文献链接或页码,建议通过PubMed或Google Scholar按标题检索。

背景信息

CAP2 (Cyclase-Associated Protein 2) is a conserved actin-binding protein involved in regulating actin dynamics, critical for cellular processes like cell motility, adhesion, and intracellular trafficking. It interacts with adenylate cyclase and cofilin to promote actin filament depolymerization and severing, ensuring cytoskeletal remodeling. CAP2 is expressed in various tissues, with notable roles in neuronal development, cardiac function, and muscle maintenance. Studies highlight its importance in neuronal migration and synapse formation, while its dysregulation is linked to neurodevelopmental disorders and cardiomyopathies. Recent research also implicates CAP2 in cancer progression, where altered expression correlates with metastasis and poor prognosis. As a multifunctional adaptor protein, CAP2’s interactions with signaling pathways (e.g., Ras, Rho GTPases) underscore its regulatory versatility. Antibodies targeting CAP2 are vital tools for investigating its localization, expression levels, and mechanistic contributions in disease models, offering potential diagnostic or therapeutic avenues. Current challenges include elucidating isoform-specific functions and tissue-dependent roles, necessitating further in vivo and clinical studies.

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