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Rabbit Monoclonal SF20 Antibody

  • 中文名： SF20抗体
  • 别    名： IL25; IL27; SF20; IL27w; C19orf10; R33729_1; EUROIMAGE1875335
货号: IPDX22221
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 1/500-1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesIL25; IL27; SF20; IL27w; C19orf10; R33729_1; EUROIMAGE1875335
Entrez GeneID56005
WB Predicted band sizeCalculated MW: 19 kDa; Observed MW: 19 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenRecombinant protein of human SF20
FormulationPurified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

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参考文献

以下是关于SF20抗体的参考文献示例(注：以下信息为模拟生成，可能不完全对应实际文献，建议通过学术数据库核实)：

1. **"SF20: A Novel Cell Surface Antigen Expressed on Human T-Lymphoblastic Malignancies"**

*作者：Knowles RW, et al.*

摘要：该研究鉴定SF20为T细胞急性淋巴细胞白血病(T-ALL)表面的特异性标志物，证实其可作为白血病诊断及靶向治疗的潜在靶点。

2. **"Targeting SF20 in Solid Tumors: Immunohistochemical Analysis in Melanoma"**

*作者：Houghton AN, et al.*

摘要：探讨SF20在黑色素瘤中的表达，显示其在部分肿瘤细胞表面高表达，提示其可能用于抗体偶联药物或免疫治疗的开发。

3. **"Molecular Cloning and Characterization of SF20: Association with T-Cell Activation"**

*作者：Seed B, et al.*

摘要：通过基因克隆解析SF20的分子结构，发现其参与T细胞受体信号通路，可能与免疫调节功能相关。

4. **"SF20 Antibody in Autoimmune Disease: Modulating T-Cell Response"**

*作者：Ochs HD, et al.*

摘要：研究SF20抗体在自身免疫模型中的作用，显示其可通过抑制T细胞过度活化缓解疾病症状。

**建议**：以上信息为基于学术文献结构的模拟，实际文献请通过PubMed、Google Scholar等平台以“SF20 antibody”或“SF20 antigen”为关键词检索。

背景信息

The SF20 antibody is a monoclonal antibody primarily recognized for its reactivity with a cytoskeleton-associated protein expressed in various mammalian cells. Initially characterized in the context of cellular structure and adhesion studies, it targets an antigen associated with intermediate filaments or related cytoskeletal components, potentially playing a role in maintaining cell integrity and motility. SF20 has been utilized in immunofluorescence, immunohistochemistry, and Western blotting to visualize cytoskeletal architecture in cultured cells and tissue samples, particularly in studies focusing on cell differentiation, wound healing, and cancer metastasis. Its epitope is suggested to reside in a conserved region of the target protein, enabling cross-species reactivity in experimental models. Research involving SF20 has contributed to understanding cytoskeletal dynamics in pathological conditions, including epithelial-mesenchymal transition (EMT) in tumors and fibroblast activation in fibrotic diseases. Despite its utility, the precise molecular identity of the SF20 antigen remains partially undefined, warranting further investigation to clarify its biological role and potential diagnostic or therapeutic applications.

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