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Rabbit Monoclonal RBM43 Antibody

  • 中文名： RBM43抗体
  • 别    名： C2orf38
货号: IPDX22219
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 1/500-1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesC2orf38
Entrez GeneID375287
WB Predicted band sizeCalculated MW: 41 kDa; Observed MW: 41 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenRecombinant protein of human RBM43
FormulationPurified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

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参考文献

以下是关于RBM43抗体的3篇参考文献示例(内容基于假设性研究，实际文献需通过学术数据库验证)：

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1. **文献名称**：*RBM43 regulates RNA splicing and promotes colorectal cancer progression*

**作者**：Li X, Wang Y, Zhang H, et al.

**摘要**：本研究利用RBM43特异性抗体(Western blot验证)，发现RBM43在结直肠癌中高表达，并通过调控靶基因(如EGFR)的选择性剪接促进肿瘤侵袭。抗体在免疫组化中证实了RBM43与患者预后不良的相关性。

2. **文献名称**：*Developmental expression and functional analysis of RBM43 in mouse embryogenesis*

**作者**：Smith J, Brown K, Tanaka R.

**摘要**：通过RBM43多克隆抗体(经免疫沉淀验证)分析小鼠胚胎组织，发现RBM43在神经管和心脏发育中高度表达，CRISPR敲除实验表明其缺失导致胚胎致死，提示其在发育中具有关键RNA调控功能。

3. **文献名称**：*RBM43 interacts with SMN complex and is linked to spinal muscular atrophy pathology*

**作者**：Garcia M, Lee S, Müller U.

**摘要**：使用RBM43抗体(兔源，免疫荧光验证)发现其与运动神经元存活(SMN)蛋白共定位，患者脊髓样本中RBM43表达异常，提示其可能参与脊髓性肌萎缩症的RNA代谢失调机制。

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*注：以上文献为模拟内容，实际研究需查阅PubMed、Web of Science等数据库。建议用关键词“RBM43 antibody”或“RBM43 function”检索最新论文。*

背景信息

The RBM43 (RNA Binding Motif Protein 43) antibody is a tool used to study the RBM43 protein, a member of the RNA-binding protein family involved in post-transcriptional gene regulation. RBM43 contains conserved RNA-binding domains, such as the RNA recognition motif (RRM), which enable interactions with RNA molecules to modulate splicing, stability, or translation. Though less characterized than other RBM family members, RBM43 is implicated in developmental processes, cellular differentiation, and stress responses. Research suggests its potential role in spermatogenesis, neural development, and tumorigenesis, with altered expression observed in certain cancers. The RBM43 antibody is primarily employed in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect protein expression levels, subcellular localization, and tissue distribution. Its development often involves immunizing hosts with RBM43-derived peptides or recombinant proteins, followed by purification and validation for specificity. Studies utilizing this antibody aim to unravel RBM43's molecular interactions, regulatory networks, and pathophysiological relevance, particularly in contexts like cancer biology or neurological disorders. However, comprehensive functional insights remain limited, necessitating further research to clarify its exact mechanisms and therapeutic potential.

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