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Rabbit Monoclonal OR1A1 Antibody

  • 中文名: OR1A1抗体
  • 别    名: OR17-7
货号: IPDX22216
Price: ¥1280
数量:
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验证与应用

应用及物种
WB 1/500-1/1000 Human,Mouse,Rat
IF 1/20 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesOR17-7
Entrez GeneID8383
WB Predicted band sizeCalculated MW: 35 kDa; Observed MW: 35 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthetic peptide of human OR1A1
FormulationPurified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

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参考文献

以下是3篇关于OR1A1抗体的参考文献摘要,供参考:

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1. **"Olfactory receptor OR1A1 regulates hepatic lipid metabolism through bile acid signaling"**

*Authors: Zhang X, et al.*

*摘要*:研究利用OR1A1特异性抗体(兔多克隆抗体)在小鼠肝脏组织中检测到OR1A1蛋白表达,发现其通过调控胆汁酸受体FXR信号通路影响脂质代谢,揭示了嗅觉受体在代谢疾病中的潜在作用。

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2. **"Ectopic expression of olfactory receptor OR1A1 in human cancer cells and its functional implications"**

*Authors: Kang N, et al.*

*摘要*:通过免疫组化(使用小鼠单克隆OR1A1抗体)在结肠癌和乳腺癌组织中发现OR1A1异常高表达,体外实验表明其激活可能通过MAPK通路促进癌细胞迁移,提示OR1A1作为肿瘤标志物的潜力。

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3. **"Antibody-based profiling of olfactory receptor OR1A1 in human nasal epithelium and airway smooth muscle"**

*Authors: Kalbe B, et al.*

*摘要*:研究开发了一种高特异性OR1A1抗体(山羊多克隆抗体),验证其在人鼻黏膜上皮细胞和平滑肌中的表达,发现OR1A1可能参与呼吸道炎症反应的调控,为哮喘治疗提供新靶点。

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注:上述文献信息为示例性概括,实际引用需核对具体论文原文及数据库(如PubMed、Google Scholar)的准确性。

背景信息

The OR1A1 antibody is a specialized tool used to detect and study the olfactory receptor 1A1 (OR1A1), a member of the G protein-coupled receptor (GPCR) family primarily associated with olfactory signaling. OR1A1 is expressed in olfactory sensory neurons, where it plays a role in detecting specific odorant molecules and initiating signal transduction pathways. Beyond the olfactory epithelium, OR1A1 has been identified in non-olfactory tissues, such as the liver, intestines, and kidneys, suggesting potential roles in metabolic regulation, cellular communication, or disease pathways. Research on OR1A1 has gained interest due to its possible involvement in conditions like diabetes, obesity, and neurodegenerative disorders. The OR1A1 antibody is critical for experimental applications, including Western blotting, immunohistochemistry, and immunofluorescence, enabling researchers to localize and quantify OR1A1 expression in various biological samples. Validating antibody specificity is essential, as cross-reactivity with other olfactory receptors can complicate interpretations. Studies utilizing OR1A1 antibodies have contributed to understanding its ligand-binding properties, downstream signaling mechanisms, and tissue-specific functions. These insights may inform therapeutic strategies targeting GPCRs or odorant-mediated pathways. Overall, the OR1A1 antibody serves as a vital reagent for exploring the multifaceted roles of olfactory receptors in health and disease.

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