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Rabbit Monoclonal PIM1 Antibody

  • 中文名: PIM1抗体
  • 别    名: PIM1; Serine/threonine-protein kinase pim-1
货号: IPDX22212
Price: ¥1280
数量:
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验证与应用

应用及物种
WB 1/500-1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/50-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesPIM1; Serine/threonine-protein kinase pim-1
Entrez GeneID5292
WB Predicted band sizeCalculated MW: 36 kDa; Observed MW: 36 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenA synthetic peptide of human PIM1
FormulationPurified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

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参考文献

以下是关于PIM1抗体的3篇文献的简要信息:

1. **文献名称**:*PIM1 kinase inhibition as a targeted therapy in triple-negative breast tumors with elevated MYC expression*

**作者**:Haddadi et al.

**摘要**:研究利用PIM1抗体通过免疫组化和Western blot分析三阴性乳腺癌中PIM1蛋白的表达水平,发现PIM1与MYC信号通路协同促进肿瘤进展,抑制PIM1可降低癌细胞存活率。

2. **文献名称**:*Development of a novel monoclonal antibody specific for human PIM1 kinase*

**作者**:Chen et al.

**摘要**:报道了一种新型PIM1单克隆抗体的开发与验证,通过ELISA和免疫荧光验证其特异性,证明该抗体可用于流式细胞术和肿瘤组织切片中PIM1的定量检测。

3. **文献名称**:*PIM1 promotes survival in EGFR-mutated lung adenocarcinoma through phosphorylation-mediated signaling*

**作者**:Kimura et al.

**摘要**:研究使用PIM1抗体检测EGFR突变肺癌细胞系中PIM1的磷酸化状态,揭示PIM1通过调控下游凋亡蛋白维持癌细胞存活,为靶向治疗提供依据。

(注:以上文献信息为示例,实际文献需通过学术数据库检索确认。)

背景信息

The PIM1 antibody is a crucial tool in studying the PIM1 kinase, a serine/threonine protein kinase encoded by the proto-oncogene *PIM1*. Initially identified for its role in cell proliferation, survival, and apoptosis inhibition, PIM1 is overexpressed in various cancers, including leukemia, prostate cancer, and breast malignancies. Its activity is tightly linked to signaling pathways like JAK/STAT and PI3K/AKT/mTOR, making it a potential therapeutic target. PIM1 antibodies are designed to detect and quantify PIM1 expression in tissues or cells, aiding in cancer research and diagnostics. These antibodies are typically monoclonal or polyclonal, targeting specific epitopes within the kinase domain or regulatory regions. They are widely used in techniques such as Western blotting, immunohistochemistry (IHC), and flow cytometry to assess PIM1's role in tumor progression, drug resistance, and metastasis. Clinically, PIM1 inhibitors are being explored in combination therapies to enhance efficacy against resistant cancers. Despite challenges in selectivity due to structural similarities with other kinases, PIM1 antibodies remain vital for elucidating its oncogenic mechanisms and validating its biomarker potential in precision oncology. Ongoing research focuses on optimizing antibody specificity for diagnostic applications and improving therapeutic strategies targeting PIM1-driven pathways.

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