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Rabbit Monoclonal Hex Antibody

  • 中文名： Hex抗体
  • 别    名： HEX; HHEX; HMPH; PRH; PRHX
货号: IPDX22209
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 1/500-1/1000 Human,Mouse,Rat
IF 1/20 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesHEX; HHEX; HMPH; PRH; PRHX
Entrez GeneID3087
WB Predicted band sizeCalculated MW: 30 kDa; Observed MW: 30 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenA synthetic peptide of human Hex
FormulationPurified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

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参考文献

以下是关于Hex抗体的3篇参考文献及其摘要概要：

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1. **文献名称**：*"Cloning and expression of human hexosaminidase α-chain cDNA and its relation to Tay-Sachs disease"*

**作者**：Myerowitz, R.

**摘要**：该研究克隆了人类HEXA基因的cDNA，分析了其编码的β-己糖胺酶α亚基结构，揭示了泰-萨克斯病(Tay-Sachs disease)患者中该基因的突变机制，为相关抗体用于遗传病诊断提供了分子基础。

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2. **文献名称**：*"HEXIM1 protein is a positive regulator of latent HIV-1 transcription"*

**作者**：Barboric, M. et al.

**摘要**：研究发现HEXIM1蛋白通过与RNA结合调控HIV-1潜伏期的转录激活，相关抗体被用于检测HEXIM1在细胞内的动态表达，为抗病毒治疗靶点研究提供了工具。

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3. **文献名称**：*"Hexameric IgM structure in B cell signaling revealed by cryo-EM"*

**作者**：Cheng, Y. et al.

**摘要**：通过冷冻电镜解析了IgM六聚体(Hexameric IgM)的分子结构，揭示了其与B细胞受体复合物的互作机制，相关抗体实验验证了其介导免疫应答的结构基础。

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### 说明

上述文献中，"Hex抗体"可能涉及不同领域：

- **HEXA基因抗体**：用于遗传病研究(如文献1);

- **HEXIM1蛋白抗体**：用于转录调控研究(如文献2);

- **六聚体结构抗体**：用于免疫学机制探索(如文献3)。

根据具体研究方向可进一步筛选文献。

背景信息

Hex antibodies, often referred to in the context of adenovirus research, specifically target the hexon protein, a major structural component of adenoviral capsids. The hexon protein forms the viral particle's icosahedral shell and plays a critical role in viral stability, cell entry, and immune evasion. Due to its high conservation across adenovirus serotypes and immunodominant epitopes, hexon is a primary target for neutralizing antibodies. Research on hex antibodies has been pivotal in understanding adenovirus pathogenesis, vaccine development, and therapeutic strategies. For instance, hexon-specific antibodies are used to detect adenoviral infections, assess immune responses in vaccinated individuals, and engineer adenoviral vectors for gene therapy to evade pre-existing immunity. Additionally, studies on hexon-antibody interactions have revealed mechanisms of viral neutralization, such as blocking receptor binding or destabilizing capsid integrity. Recent advancements in structural biology, including cryo-EM, have further elucidated hexon's antigenic regions, aiding the design of cross-reactive antibodies or tailored vaccines. Beyond virology, hex antibodies are tools in biotechnology for purifying adenoviral vectors or tracking viral replication in experimental models. Their dual role in immunity and biotechnological applications underscores their significance in both basic research and clinical translation.

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