| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | ERV29 |
| Entrez GeneID | 6836 |
| WB Predicted band size | Calculated MW: 30 kDa; Observed MW: 30 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthetic peptide of human SURF4 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
+ +
以下是关于 **Surfeit Locus Protein 4 (SURF4)** 抗体的3篇参考文献示例(基于研究主题模拟，具体文献需根据实际数据库检索验证)：
---
1. **标题**: *"SURF4 maintains endoplasmic reticulum export of COPII vesicles by regulating cargo concentration"*
**作者**: Smith A, et al.
**摘要**: 研究利用SURF4特异性抗体，通过免疫荧光和Western blot验证SURF4在内质网-高尔基体运输中的作用，发现其通过调控COPII囊泡的货物装载促进分泌蛋白的转运。
2. **标题**: *"Surfeit locus protein 4 as a novel biomarker in hepatocellular carcinoma: antibody-based detection and clinical significance"*
**作者**: Chen L, et al.
**摘要**: 开发了一种针对SURF4的单克隆抗体，通过免疫组化分析肝癌组织样本，发现SURF4高表达与患者预后不良相关，提示其作为癌症治疗靶点的潜力。
3. **标题**: *"SURF4 interacts with viral replication machinery to facilitate hepatitis C virus assembly"*
**作者**: Tanaka K, et al.
**摘要**: 使用SURF4抗体进行共免疫沉淀实验，发现SURF4与HCV非结构蛋白相互作用，调控病毒颗粒在内质网的组装，为抗病毒治疗提供新方向。
4. **标题**: *"Surfeit 4 regulates lipid metabolism by modulating LDL receptor trafficking"*
**作者**: Gupta R, et al.
**摘要**: 通过SURF4抗体敲低实验和免疫印迹分析，证明SURF4通过调控LDL受体从内质网到细胞膜的转运影响胆固醇稳态，与动脉粥样硬化相关。
---
**注**：以上文献为示例性质，实际引用需通过PubMed、Google Scholar等平台检索真实存在的论文，并核对作者、标题及摘要内容。建议使用关键词 **"SURF4 antibody"** 或 **"Surfeit 4 protein function"** 进行精准查询。
**Background of Surfeit Locus Protein 4 (SURF4) Antibody**
Surfeit locus protein 4 (SURF4) is a conserved transmembrane protein encoded by the *SURF4* gene, part of the surfeit gene cluster on chromosome 9q34. This gene cluster comprises six tightly linked housekeeping genes (*SURF1–SURF6*) with diverse functions. SURF4 localizes to the endoplasmic reticulum (ER) and Golgi apparatus, playing critical roles in ER-associated processes, including COPII vesicle-mediated protein transport, cholesterol metabolism, and cargo receptor activity. It facilitates the secretion of specific proteins, such as progranulin and proinsulin, by interacting with cargo molecules and promoting their packaging into transport vesicles.
SURF4 antibodies are essential tools for studying its expression, localization, and function in cellular and disease contexts. These antibodies are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to analyze SURF4 levels in tissues or cell lines. Research highlights SURF4's involvement in cancer progression (e.g., hepatocellular carcinoma, colorectal cancer) due to its role in sustaining tumor cell proliferation and metastasis. Additionally, SURF4 is implicated in metabolic disorders, such as dyslipidemia, and neurodegenerative diseases linked to progranulin deficiency.
Current studies focus on SURF4 as a potential therapeutic target or biomarker, leveraging antibody-based approaches to explore its regulatory mechanisms in health and disease. Its dual role in protein trafficking and disease pathways underscores its biological and clinical significance.
×
