| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | ESP2; HED2; ZYX; Zyxin2 |
| Entrez GeneID | 7791 |
| WB Predicted band size | Calculated MW: 61 kDa; Observed MW: 78 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Rat |
| Immunogen | A synthetic peptide of human Zyxin |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于ZYX(Zyxin)抗体的参考文献示例(注：以下内容为虚构，仅用于格式演示)：
1. **标题**：*Zyxin regulates cell migration by stabilizing focal adhesion dynamics*
**作者**：Smith A, et al.
**摘要**：本研究利用ZYX抗体进行免疫荧光染色，揭示了Zyxin蛋白在黏着斑组装和细胞迁移中的动态定位，证实其通过调控肌动蛋白重构影响细胞运动能力。
2. **标题**：*Mechanical stress-induced Zyxin expression in cardiomyocytes*
**作者**：Lee B, et al.
**摘要**：通过Western blot和免疫组化(使用ZYX抗体)，作者发现机械应力可显著上调心肌细胞中Zyxin的表达，提示其在心脏机械信号传导中的作用。
3. **标题**：*Zyxin knockdown impairs cancer cell invasion via altered adhesion signaling*
**作者**：Zhang C, et al.
**摘要**：研究采用ZYX抗体验证siRNA敲低效果，证明Zyxin缺失通过降低侵袭伪足形成抑制癌细胞转移，为靶向Zyxin的抗肿瘤策略提供依据。
4. **标题**：*Developmental expression pattern of Zyxin in zebrafish embryos*
**作者**：Garcia D, et al.
**摘要**：通过免疫组织化学(使用ZYX抗体)分析斑马鱼胚胎，发现Zyxin在体节形成和神经嵴细胞迁移过程中呈现时空特异性表达。
(提示：如需真实文献，建议在PubMed或Web of Science中检索关键词“Zyxin antibody”或“Zyxin application”。)
Zyxin (ZYX) is a cytoskeletal protein primarily localized at focal adhesions, dynamic structures that mediate cell-extracellular matrix (ECM) interactions. It plays a critical role in cell motility, mechanotransduction, and adhesion signaling by acting as a scaffold for protein-protein interactions. Structurally, Zyxin contains multiple LIM domains, which facilitate its binding to partners like α-actinin, VASP, and members of the Ena/VASP family, thereby regulating actin filament organization and cell migration. Its nucleo-cytoplasmic shuttling ability also links mechanical cues to gene expression. Dysregulation of Zyxin has been implicated in pathological processes, including cancer metastasis and cardiovascular diseases, due to its role in modulating cellular responses to mechanical stress.
ZYX antibodies are essential tools for studying these biological processes. They are widely used in techniques such as immunofluorescence, Western blotting, and immunohistochemistry to visualize Zyxin's subcellular distribution, expression levels, and interactions under varying mechanical or pathological conditions. Commercial ZYX antibodies are typically raised against specific epitopes (e.g., human Zyxin N-terminal or LIM domains) and validated for cross-reactivity in multiple species. Their applications span basic research in cell biology, cancer mechanobiology, and tissue engineering, providing insights into how mechanical forces influence cellular behavior and disease progression.
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