| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | WNT13; Wnt2b; XWNT2 |
| Entrez GeneID | 7482 |
| WB Predicted band size | Calculated MW: 44 kDa; Observed MW: 44 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthetic peptide of human Wnt2b |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
+ +
以下是关于Wnt2b抗体的3篇示例参考文献(内容为示例，非真实文献，仅供格式参考)：
1. **文献名称**：*Wnt2b regulates retinal vascular development through endothelial cell signaling*
**作者**：Smith A, et al.
**摘要**：本研究利用Wnt2b特异性抗体，通过免疫组化技术揭示了Wnt2b在小鼠视网膜血管生成中的表达模式，并证明其通过调控内皮细胞增殖影响血管网络的形成。
2. **文献名称**：*A novel Wnt2b antibody reveals its role in neural crest cell migration*
**作者**：Chen L, et al.
**摘要**：作者开发了一种高特异性Wnt2b单克隆抗体，通过斑马鱼模型证明Wnt2b在神经嵴细胞迁移中的关键作用，并发现其缺失导致颅面发育异常。
3. **文献名称**：*Wnt2b overexpression in gastric cancer: Correlation with antibody-based detection and clinical prognosis*
**作者**：Tanaka K, et al.
**摘要**：通过免疫组织化学(使用抗Wnt2b抗体)分析胃癌组织样本，发现Wnt2b高表达与患者生存率降低显著相关，提示其作为潜在肿瘤标志物的价值。
如需真实文献，建议通过PubMed或Google Scholar搜索关键词“Wnt2b antibody” + 具体研究领域(如发育、癌症等)。
**Background of Wnt2b Antibody**
The Wnt2b antibody is a specialized tool used to detect and study the Wnt2b protein, a member of the Wnt family of secreted glycoproteins. Wnt proteins play critical roles in embryonic development, tissue homeostasis, and cellular signaling, particularly through the evolutionarily conserved Wnt/β-catenin (canonical) and non-canonical pathways. Wnt2b, encoded by the *WNT2B* gene, shares structural homology with Wnt2 and is implicated in regulating cell proliferation, differentiation, and polarity. It is highly expressed during embryogenesis, influencing organogenesis (e.g., eye, brain, and kidney) and stem cell maintenance. Dysregulation of Wnt2b signaling has been linked to pathological conditions, including cancers (e.g., colorectal, gastric), ocular disorders, and metabolic diseases.
The Wnt2b antibody enables researchers to investigate the protein’s expression, localization, and functional mechanisms in various biological contexts. It is widely utilized in techniques like Western blotting, immunohistochemistry, and immunofluorescence to validate Wnt2b presence in tissue samples or cell lines. Specificity and validation (e.g., knockout controls) are essential to ensure accurate detection, given the structural similarities among Wnt family members. By studying Wnt2b with such antibodies, researchers aim to unravel its role in developmental pathways, disease progression, and potential therapeutic targeting. This tool remains vital for advancing insights into Wnt-driven biology and translational applications.
×
