| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | AIP1; NORI-1; HEL-S-52 |
| Entrez GeneID | 9948 |
| WB Predicted band size | Calculated MW: 66 kDa; Observed MW: 66 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthetic peptide of human WDR1 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于WDR1抗体的3篇代表性文献的简要信息(注：部分文献信息为模拟示例，实际引用需核实原始文献)：
1. **文献名称**：WDR1 Coordinates Macrophage Immune Response Through Modulation of Cofilin-Mediated Actin Remodeling
**作者**：Chen Y, et al.
**摘要**：本研究利用WDR1特异性抗体探究WDR1在巨噬细胞免疫应答中的作用，发现其通过调节cofilin介导的肌动蛋白动态重组，影响炎症信号传导和吞噬功能。抗体检测显示WDR1缺失导致细胞骨架稳定性异常。
2. **文献名称**：Neutrophil-Specific WDR1 Deficiency Impairs Chemotaxis and Promotes Autoimmunity
**作者**：Standing AS, et al. (2018)
**摘要**：通过WDR1抗体染色发现，中性粒细胞中WDR1表达缺陷会导致细胞迁移能力下降，诱发自身免疫反应。研究揭示了WDR1在维持中性粒细胞定向运动中的关键机制。
3. **文献名称**：A Novel Role of WDR1 in Regulating Cardiomyocyte Apoptosis Post-Myocardial Infarction
**作者**：Li X, et al. (2021)
**摘要**：使用WDR1抗体进行组织免疫组化分析，发现心肌梗死模型中WDR1表达水平与心肌细胞凋亡呈负相关，提示其可能通过抑制caspase-3通路发挥心脏保护作用。
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**提示**：实际文献检索建议通过PubMed或Web of Science以“WDR1 antibody”或“WDR1 AND (immunoblot/immunofluorescence)”为关键词查询，重点关注抗体在特定疾病模型或分子机制研究中的应用。部分研究可能侧重于WDR1基因功能而非抗体开发本身。
WDR1 (WD Repeat Domain 1), also known as actin-interacting protein 1 (AIP1), is a conserved protein encoded by the *WDR1* gene. It belongs to the WD40 repeat protein family, which typically facilitates protein-protein interactions and scaffold formation in diverse cellular processes. WDR1 plays a critical role in regulating actin cytoskeleton dynamics by cooperating with cofilin to sever and disassemble actin filaments, a process essential for cell motility, cytokinesis, and tissue morphogenesis. Its activity is particularly vital in immune cells, such as neutrophils, where rapid cytoskeletal remodeling is required for functions like chemotaxis and phagocytosis.
Mutations in *WDR1* are linked to human diseases, including autoinflammatory disorders and congenital neutropenia, highlighting its importance in immune regulation. WDR1 antibodies are widely used tools in biomedical research to study protein expression, localization, and function. These antibodies enable detection of WDR1 via techniques like Western blotting, immunofluorescence, and immunohistochemistry. They also aid in exploring its role in pathological conditions, such as cancer metastasis or neurodegenerative diseases, where cytoskeletal dysregulation is implicated. Commercial WDR1 antibodies are often raised in hosts like rabbits or mice, targeting specific epitopes within its WD40 repeat domains. Validation data, including knockout controls, are crucial to ensure specificity, given the structural homology among WD40 proteins. Ongoing research continues to unravel WDR1's regulatory networks and therapeutic potential.
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