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Rabbit Monoclonal USO1 Antibody

  • 中文名： USO1抗体
  • 别    名： TAP; VDP; P115
货号: IPDX22165
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 1/500-1/1000 Human,Mouse,Rat
IF 1/20 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesTAP; VDP; P115
Entrez GeneID8615
WB Predicted band sizeCalculated MW: 108 kDa; Observed MW: 108 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityMouse
ImmunogenA synthetic peptide of human Vesicle docking protein p115
FormulationPurified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

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参考文献

以下是关于USO1抗体的3篇虚构参考文献示例(仅供格式参考)：

1. **文献名称**：*USO1/p115 Antibody Reveals Its Role in Golgi-ER Retrograde Transport*

**作者**：Smith A, et al.

**摘要**：本研究利用特异性USO1抗体，证实USO1/p115蛋白通过调控COPI囊泡形成参与高尔基体-内质网逆向运输，并解析其与GM130蛋白的相互作用机制。

2. **文献名称**：*USO1 Expression in Colorectal Cancer: A Prognostic Biomarker Study*

**作者**：Chen L, et al.

**摘要**：通过免疫组化分析USO1抗体标记的肿瘤组织，发现USO1在结直肠癌中高表达且与患者生存期缩短显著相关，提示其作为潜在治疗靶点。

3. **文献名称**：*USO1 Knockdown Disrupts Amyloid-β Secretion in Neuronal Cells*

**作者**：Park J, et al.

**摘要**：利用USO1抗体进行蛋白定位及功能抑制实验，证明USO1缺失通过影响APP蛋白运输减少β-淀粉样蛋白分泌，为阿尔茨海默病机制提供新视角。

注：以上内容为模拟生成，实际文献需通过PubMed等数据库检索。

背景信息

The USO1 antibody targets the USO1 protein, also known as p115. a critical vesicle-tethering factor in eukaryotic cells. USO1 (Unc-45 Myosin Chaperone A) plays a central role in intracellular membrane trafficking, particularly in mediating the tethering of coat protein complex II (COPII)-coated vesicles during endoplasmic reticulum (ER)-to-Golgi transport. It acts as a bridge between vesicles and target membranes, facilitating SNARE complex assembly for membrane fusion. Structurally, USO1 contains a globular N-terminal domain, central coiled-coil regions, and a C-terminal acidic domain, enabling interactions with proteins like GM130 and Rab1 GTPase. Dysregulation of USO1 is linked to Golgi fragmentation, impaired secretion, and diseases such as cancer and neurodegeneration. Antibodies against USO1 are widely used in cell biology research to study Golgi dynamics, vesicular transport mechanisms, and cellular stress responses. They are employed in techniques like immunofluorescence, Western blotting, and co-immunoprecipitation to visualize USO1 localization, quantify expression levels, or explore protein-protein interactions. Commercial USO1 antibodies are typically raised against specific epitopes (e.g., human residues 200-300) and validated for cross-reactivity in model organisms. Recent studies also investigate USO1’s potential as a biomarker in certain cancers, emphasizing its translational relevance.

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