| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | 7B4; Vec; VECD; Cd144; VEcad; VE-Cad; AA408225 |
| Entrez GeneID | 12562 |
| WB Predicted band size | Calculated MW: 88 kDa; Observed MW: 90-140 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Mouse |
| Immunogen | Recombinant protein of mouse VE Cadherin |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是3篇与Cadherin 5(VE-cadherin)抗体相关的文献摘要示例(文献标题及内容为虚构模拟，仅供参考)：
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1. **"VE-cadherin Antibody Blocks Angiogenesis in Tumor Models"**
*作者：Taddei A, et al. (2017)*
**摘要**：本研究利用特异性抗VE-cadherin单克隆抗体(Clone BV9)阻断血管内皮细胞间连接，证实其在体外和小鼠肿瘤模型中显著抑制血管生成，为抗肿瘤治疗提供潜在策略。
2. **"Functional Characterization of Cadherin 5 Antibody in Vascular Permeability"**
*作者：Dejana E, et al. (2008)*
**摘要**：通过免疫沉淀和免疫荧光技术，验证了抗Cadherin 5多克隆抗体(货号：ab33168)对血管内皮细胞连接完整性的调控作用，揭示其在炎症相关血管渗漏中的关键角色。
3. **"VE-cadherin Phosphorylation Detection Using Phospho-specific Antibodies"**
*作者：Langer HF, et al. (2014)*
**摘要**：开发了一种针对VE-cadherin酪氨酸磷酸化位点(Y658)的抗体，证明其在动脉粥样硬化模型中可特异性识别病理状态下的内皮细胞异常连接，推动心血管疾病机制研究。
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注：以上文献信息为示例性质，实际引用需根据真实发表的论文(建议通过PubMed或Google Scholar以“VE-cadherin antibody”为关键词检索最新文献)。
Cadherin 5. also known as VE-cadherin (vascular endothelial cadherin) or CDH5. is a calcium-dependent cell adhesion protein predominantly expressed in endothelial cells. It plays a critical role in maintaining vascular integrity by regulating endothelial cell-cell junctions, controlling permeability, and supporting angiogenesis. As a key component of adherens junctions, Cadherin 5 mediates homophilic interactions to stabilize blood vessel structures and modulate signaling pathways involved in endothelial survival and remodeling.
Antibodies targeting Cadherin 5 are widely used in research to investigate vascular biology, tumor angiogenesis, and inflammatory diseases. These antibodies enable the detection, localization, and functional analysis of Cadherin 5 in techniques such as Western blotting, immunohistochemistry, and immunofluorescence. They are particularly valuable in studying endothelial barrier dysfunction in conditions like sepsis, atherosclerosis, or cancer metastasis, where vascular leakage or abnormal angiogenesis occurs. Additionally, Cadherin 5 antibodies serve as tools to explore therapeutic strategies aiming to modulate vascular growth or permeability, such as in anti-cancer therapies or regenerative medicine. Both monoclonal and polyclonal variants are available, with specificity validated across human, mouse, and rat models, reflecting its conserved role in vascular systems. Recent studies also highlight its potential as a biomarker for endothelial activation in cardiovascular and inflammatory disorders.
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