关键信息
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基因名
ELOVL1
- 应用
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别名
Ssc1; 3-keto acyl-CoA synthase ELOVL1; ELOVL fatty acid elongase 1; Very-long-chain 3-oxoacyl-CoA synthase 1
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种属
Rat
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q5U2Z8
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表达区间
Met1~Leu58
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分子量
15kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
ELOVL1, a member of the elongation of very long chain fatty acids (ELOVL) family, plays a critical role in the synthesis of long-chain fatty acids, particularly those with 24 and 26 carbon atoms. This enzyme is primarily expressed in the skin and the brain, where it is essential for maintaining the structure and function of cellular membranes. Research has shown that ELOVL1 is involved in the production of ceramides and other lipids that are crucial for skin barrier integrity and overall skin health. Disruptions in ELOVL1 function have been linked to various skin disorders and neurological conditions, highlighting its importance in both dermatological and neurological contexts. Furthermore, mutations in the ELOVL1 gene are associated with specific genetic disorders, prompting interest in its potential as a therapeutic target. Recombinant ELOVL1 protein studies aim to elucidate the enzyme's biochemical properties and mechanisms, which can provide insights into its role in disease processes and identify opportunities for developing novel interventions aimed at enhancing lipid profile and skin barrier function. As research progresses, ELOVL1 continues to be a focal point for understanding fatty acid metabolism, skin health, and related pathologies, thereby contributing to the broader field of lipid biology and therapeutics.
