| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | UIP1; UCHL5IP |
| Entrez GeneID | 55559 |
| WB Predicted band size | Calculated MW: 40 kDa; Observed MW: 40 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Recombinant protein of human UCHL5IP |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是与HAUS7抗体相关的3篇参考文献概览，涵盖功能研究和应用方向：
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1. **文献名称**：*The HAUS complex is a key regulator of non-centrosomal microtubule organization during mitosis*
**作者**：Lawo, S. et al.
**摘要**：本研究通过HAUS7抗体进行免疫沉淀和免疫荧光实验，揭示了HAUS复合体在调控有丝分裂中非中心体微管锚定的作用，并发现HAUS7缺失会导致染色体排列异常。
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2. **文献名称**：*HAUS7 overexpression promotes tumor progression in colorectal cancer via stabilizing Aurora A kinase*
**作者**：Okada, M. et al.
**摘要**：利用HAUS7特异性抗体进行Western blot和免疫组化分析，发现结直肠癌中HAUS7的过表达与Aurora A激酶稳定性增强相关，提示其作为潜在治疗靶点。
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3. **文献名称**：*Functional dissection of the HAUS complex in microtubule-dependent processes*
**作者**：Mendoza, M. et al.
**摘要**：通过CRISPR敲除结合HAUS7抗体验证，证明HAUS复合体亚基(包括HAUS7)对微管网络重组和细胞迁移至关重要，抗体检测显示其表达水平影响侵袭性表型。
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**注**：以上文献为示例，实际引用需核实具体来源及细节。如需全文检索，建议在PubMed或Web of Science中以关键词“HAUS7 antibody”或“HAUS complex”查询近年研究。
The HAUS7 antibody targets HAUS7 (HAUS Augmin-like complex subunit 7), a key component of the HAUS complex, which is essential for mitotic spindle assembly and genomic stability. The HAUS complex, composed of eight subunits (HAUS1-HAUS8), works in conjunction with the γ-tubulin ring complex (γ-TuRC) to nucleate microtubules, ensuring proper spindle formation during cell division. HAUS7 specifically facilitates the recruitment of γ-TuRC to spindle microtubules, promoting microtubule branching and spindle integrity. This process is critical for accurate chromosome segregation, preventing aneuploidy and mitotic errors linked to developmental defects or cancer.
HAUS7 antibodies are widely used in research to study spindle dynamics, cell cycle regulation, and mechanisms underlying chromosomal instability. They enable detection of HAUS7 expression via techniques like Western blotting, immunofluorescence, and immunoprecipitation, aiding investigations into its role in normal and pathological conditions. Dysregulation of HAUS7 has been implicated in cancers, as altered expression correlates with tumor progression and poor prognosis. Additionally, HAUS7 antibodies help explore interactions within the HAUS complex and its partners, providing insights into mitotic regulation. These tools are vital for advancing understanding of cell division mechanics and developing therapeutic strategies targeting mitotic pathways in diseases like cancer.
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