| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | ARD1; ARFD1; RNF46 |
| Entrez GeneID | 373 |
| WB Predicted band size | Calculated MW: 64 kDa; Observed MW: 64 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthetic peptide of human TRIM23 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于TRIM23抗体的3篇文献示例(内容为模拟，供参考)：
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1. **文献名称**: *TRIM23 Mediates Virus-Induced Autophagy via Ubiquitination of Beclin-1*
**作者**: Li X et al.
**摘要**: 本研究通过使用TRIM23特异性抗体，证明TRIM23在病毒感染过程中通过泛素化修饰Beclin-1调控自噬体形成，揭示其在抗病毒免疫中的新机制。
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2. **文献名称**: *TRIM23 Antibody Validation in Neuronal Protein Interaction Studies*
**作者**: Sato Y et al.
**摘要**: 文章验证了TRIM23抗体在神经元组织中的特异性，并发现TRIM23与突触蛋白PSD-95存在相互作用，提示其可能参与神经发育的分子通路。
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3. **文献名称**: *Role of TRIM23 in NF-κB Signaling Pathway Identified by Immunoprecipitation*
**作者**: Chen R et al.
**摘要**: 通过TRIM23抗体的免疫共沉淀实验，作者发现TRIM23通过结合IKK复合物激活NF-κB信号，为炎症反应调控提供了新靶点。
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如需真实文献，建议在PubMed或Google Scholar检索关键词“TRIM23 antibody” + “研究领域”(如自噬、癌症等)。
The TRIM23 antibody is a tool used to detect and study TRIM23 (Tripartite Motif Containing 23), a protein encoded by the *TRIM23* gene in humans. TRIM23 belongs to the TRIM family of proteins, which are characterized by a conserved N-terminal RBCC motif (RING finger, B-box, and coiled-coil domains) and a variable C-terminal region. TRIM23 functions as an E3 ubiquitin ligase due to its RING domain, enabling it to mediate protein ubiquitination, a post-translational modification critical for protein degradation, signaling, and trafficking. It also interacts with small GTPases, particularly Rab proteins, suggesting roles in intracellular vesicular transport and membrane dynamics. TRIM23 has been implicated in innate immune responses, autophagy, and neuronal processes, with studies linking it to neuroprotection and neurodegenerative diseases like Alzheimer’s. Additionally, its dysregulation is associated with cancer progression and viral infections.
The TRIM23 antibody is commonly used in techniques such as Western blotting, immunoprecipitation, and immunofluorescence to analyze protein expression, localization, and interactions. Researchers rely on its specificity (validated via knockout controls) to investigate TRIM23's molecular mechanisms in health and disease. Antibodies targeting TRIM23 are typically raised in hosts like rabbits or mice, with options for monoclonal or polyoclonal formats. Their applications span cell biology, immunology, and neuroscience, aiding in unraveling TRIM23's dual roles in ubiquitination-dependent pathways and GTPase-mediated processes.
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