| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | CDC50B |
| Entrez GeneID | 161291 |
| WB Predicted band size | Calculated MW: 39 kDa; Observed MW: 39 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Recombinant protein of human TMEM30B |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于Transmembrane Protein 30B(TMEM30B)抗体的3篇文献示例(注：文献为假设性概括，实际引用需核实)：
1. **文献名称**: "TMEM30B is a critical component of the P4-ATPase lipid flippase complex"
**作者**: Andersen JP, et al.
**摘要**: 研究揭示了TMEM30B作为P4-ATP酶复合物的辅助亚基，在磷脂跨膜转运中的作用，并利用特异性抗体验证其与ATP11B的相互作用。
2. **文献名称**: "Expression and prognostic significance of TMEM30B in gastric cancer"
**作者**: Zhang L, et al.
**摘要**: 通过免疫组化(使用抗TMEM30B抗体)发现TMEM30B在胃癌组织中高表达，其水平与患者预后不良相关，可能通过促进细胞迁移发挥作用。
3. **文献名称**: "TMEM30B deficiency disrupts lipid homeostasis in a mouse model of neurodegeneration"
**作者**: Voss CM, et al.
**摘要**: 利用TMEM30B抗体检测发现，TMEM30B缺失导致小鼠脑组织脂质分布异常，提示其在神经退行性疾病中的潜在机制。
建议通过PubMed或Google Scholar以“TMEM30B antibody”为关键词检索最新文献获取准确信息。
Transmembrane Protein 30B (TMEM30B) is a conserved eukaryotic protein integral to cellular membrane systems. It belongs to the CDC50/LEM3 family, functioning as a β-subunit for P4-ATPases (phospholipid flippases), which maintain membrane asymmetry by translocating phospholipids across lipid bilayers. TMEM30B assists in the proper localization, stability, and enzymatic activity of specific P4-ATPases, such as ATP11A/B/C, ensuring critical processes like vesicular trafficking, cell signaling, and membrane repair.
TMEM30B antibodies are essential tools for studying its expression, interaction partners, and role in cellular physiology. These antibodies enable detection and localization of TMEM30B in tissues or cultured cells via techniques like Western blotting, immunofluorescence, and immunohistochemistry. Research highlights its involvement in neurological functions, cancer progression, and lipid metabolism disorders. For example, altered TMEM30B expression has been linked to neurodevelopmental defects and chemoresistance in certain cancers, possibly due to disrupted lipid transport affecting drug permeability or signaling pathways.
Current studies also explore TMEM30B's potential as a therapeutic target or biomarker. However, its exact mechanisms and tissue-specific roles remain under investigation. Validated TMEM30B antibodies are crucial for clarifying its physiological and pathological contributions, aiding advancements in membrane biology and disease research.
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