| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Transmembrane protein 161B |
| Entrez GeneID | 153396 |
| WB Predicted band size | Calculated MW: 55 kDa; Observed MW: 55 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Recombinant protein of human TMEM161B |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
+ +
以下是关于Transmembrane Protein 161B(TMEM161B)抗体的3篇假设参考文献及其简要概括：
1. **"TMEM161B modulates glioblastoma response to chemotherapy via extracellular matrix remodeling"**
- **作者**: Smith A, et al.
- **摘要**: 本研究利用CRISPR筛选结合TMEM161B特异性抗体进行Western blot和免疫荧光分析，发现TMEM161B表达缺失导致胶质母细胞瘤对替莫唑胺敏感性增加，机制涉及细胞外基质蛋白(如层粘连蛋白)分泌异常。
2. **"Mutations in TMEM161B cause craniosynostosis through disrupted cell adhesion signaling"**
- **作者**: Johnson L, et al.
- **摘要**: 通过全外显子测序在颅缝早闭患者中鉴定出TMEM161B功能缺失突变，并利用兔源多克隆抗体进行免疫组化，证实突变导致颅骨成骨细胞中TMEM161B蛋白表达下降及Wnt/β-catenin信号通路异常。
3. **"Development of a monoclonal antibody targeting human TMEM161B for neuronal localization studies"**
- **作者**: Brown K, et al.
- **摘要**: 报道一种新型小鼠抗人TMEM161B单克隆抗体的开发与验证，该抗体在免疫沉淀和免疫细胞化学中显示高特异性，成功应用于小鼠脑组织切片中TMEM161B的突触前膜定位分析。
*注：以上文献为示例性内容，实际研究中需以真实发表的论文为准。*
The transmembrane protein 161B (TMEM161B) is a poorly characterized multi-pass membrane protein encoded by the TMEM161B gene, conserved across species. While its precise physiological role remains unclear, TMEM161B is hypothesized to participate in cellular signaling, ion transport, or cell adhesion processes due to its structural features, including multiple transmembrane domains. Recent studies have linked TMEM161B to neurological disorders and cancer. For instance, mutations in TMEM161B have been associated with neurodevelopmental abnormalities, while dysregulated expression has been observed in gliomas and breast cancers, suggesting potential roles in tumor progression or neural function.
Antibodies targeting TMEM161B are essential tools for investigating its expression, localization, and molecular interactions. These antibodies, typically developed in rabbit or mouse hosts using immunogenic peptide sequences from conserved regions, enable applications such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Validation often includes knockout cell line controls to confirm specificity. Research utilizing TMEM161B antibodies has helped identify its subcellular localization in endoplasmic reticulum and plasma membrane compartments. However, the functional characterization of TMEM161B remains an active area of research, with antibodies playing a critical role in elucidating its involvement in disease pathways and potential therapeutic targeting. Commercial availability of these reagents has accelerated studies exploring TMEM161B's role in cellular physiology and pathology.
×
