首页 / 产品 / 抗体 / 一抗

Rabbit Monoclonal TIAM2 Antibody

  • 中文名： TIAM2抗体
  • 别    名： STEF; TIAM-2
货号: IPDX22096
Price： ￥1280
数量：
大包装询价

验证与应用

应用及物种
WB 1/500-1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/50-1/100 Human,Mouse,Rat
ICC 1/50-1/200 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesSTEF; TIAM-2
Entrez GeneID26230
WB Predicted band sizeCalculated MW: 190 kDa; Observed MW: 190 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenRecombinant protein of human TIAM2
FormulationPurified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

+ +

参考文献

以下是3篇与TIAM2抗体相关的文献示例(内容为模拟概括，建议通过学术数据库核实最新文献)：

---

1. **文献名称**: *"TIAM2 promotes cell proliferation and invasion in triple-negative breast cancer through activation of the AKT/GSK-3β/β-catenin pathway"*

**作者**: Zhang Y, et al.

**摘要**: 本研究利用TIAM2特异性抗体进行Western blot和免疫组化分析，发现TIAM2在乳腺癌中高表达并通过激活AKT/β-catenin通路促进肿瘤侵袭，提示其可作为治疗靶点。

---

2. **文献名称**: *"Role of TIAM2 in regulating neuronal migration during cortical development"*

**作者**: Lee S, et al.

**摘要**: 通过TIAM2抗体的免疫荧光染色，作者揭示了TIAM2在小鼠大脑皮层神经元迁移中的关键作用，并发现其缺失导致Rho GTPase信号异常和神经元定位障碍。

---

3. **文献名称**: *"TIAM2 as a potential biomarker for colorectal cancer metastasis"*

**作者**: Wang H, et al.

**摘要**: 研究采用TIAM2抗体对结肠癌组织进行检测，发现TIAM2表达水平与淋巴结转移和患者预后显著相关，提示其作为转移预测生物标志物的潜力。

---

如需具体文献，建议通过 **PubMed** (https://pubmed.ncbi.nlm.nih.gov) 或 **Web of Science** 以“TIAM2 antibody”为关键词检索最新研究。

背景信息

The TIAM2 antibody is a crucial tool in studying the role of TIAM2 (T-cell lymphoma invasion and metastasis 2), a guanine nucleotide exchange factor (GEF) that activates Rho-family GTPases, particularly Rac1. TIAM2 regulates cellular processes such as cytoskeletal reorganization, cell migration, and adhesion, which are central to cancer metastasis and neuronal development. It is encoded by the TIAM2 gene, located on human chromosome 6q25.3. and shares structural homology with TIAM1 but exhibits distinct tissue expression patterns, with higher levels in the brain and testis. Dysregulation of TIAM2 has been implicated in cancers, including gliomas and prostate cancer, where it may promote invasive behavior. Researchers use TIAM2 antibodies primarily in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to detect protein expression, localization, and interactions in cell lines or tissue samples. These antibodies help elucidate TIAM2's involvement in signaling pathways, such as Wnt or PDGF, and its crosstalk with other metastasis-related proteins. Validation often includes knockout controls or siRNA-based silencing to confirm specificity. Commercial TIAM2 antibodies are typically raised in rabbits or mice, targeting epitopes within the N-terminal or C-terminal regions. Proper storage and optimized dilution protocols are critical for maintaining antibody performance in experimental settings.

客户数据及评论

折叠内容

大包装询价

×