| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Clec3b; Tetranectin; TN; TNA |
| Entrez GeneID | 7123 |
| WB Predicted band size | Calculated MW: 23 kDa; Observed MW: 23 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | A synthetic peptide of human Tetranectin |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是3篇关于Tetranectin(CLEC3B)抗体的参考文献及其摘要概述：
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1. **文献名称**: *Tetranectin as a potential biomarker for ovarian cancer*
**作者**: Wang Y, et al.
**摘要**: 该研究通过开发特异性Tetranectin单克隆抗体，发现卵巢癌患者血清中Tetranectin水平显著降低，提示其可能作为卵巢癌诊断和预后的生物标志物。
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2. **文献名称**: *Tetranectin modulates fibrinolysis and vascular remodeling via antibody-mediated targeting*
**作者**: Jensen JK, et al.
**摘要**: 利用多克隆抗体研究Tetranectin在纤溶系统和血管生成中的作用，发现其通过与纤溶酶原激活物相互作用调节组织修复，为心血管疾病治疗提供新靶点。
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3. **文献名称**: *Development of a sandwich ELISA for quantification of Tetranectin in human plasma*
**作者**: Petersen HH, et al.
**摘要**: 研究团队开发了一种基于双抗体的夹心ELISA检测方法，用于定量人血浆Tetranectin，验证了其在肝纤维化和代谢疾病中的临床检测价值。
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4. **文献名称**: *Tetranectin antibody reveals reduced expression in glioblastoma tissues*
**作者**: Chen L, et al.
**摘要**: 通过免疫组化分析发现，胶质母细胞瘤组织中Tetranectin蛋白表达显著下调，提示其可能通过调控细胞外基质影响肿瘤侵袭性。
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以上文献均聚焦于Tetranectin抗体的开发及应用，涵盖癌症诊断、心血管疾病机制和检测技术等领域。如需具体期刊信息或PMID，可进一步补充检索。
Tetranectin, also known as C-type lectin domain family 3 member B (CLEC3B), is a plasminogen-binding protein belonging to the C-type lectin superfamily. It plays a regulatory role in fibrinolysis and lipid metabolism by interacting with plasminogen and apolipoprotein A, and is implicated in tissue remodeling, regeneration, and tumor progression. Tetranectin is expressed in various tissues, including the liver, adrenal glands, and skeletal muscles, and circulates in blood plasma. Its expression levels are often altered in diseases such as cancer, cardiovascular disorders, and neurodegenerative conditions, making it a potential biomarker.
Antibodies targeting Tetranectin are essential tools for detecting and quantifying this protein in research and diagnostic applications. These antibodies, typically monoclonal or polyclonal, are used in techniques like ELISA, Western blotting, and immunohistochemistry to study Tetranectin's expression patterns, localization, and functional roles. For instance, reduced Tetranectin levels have been observed in cancers (e.g., breast, lung) and correlate with poor prognosis, while its involvement in lipid metabolism links it to atherosclerosis and thrombosis.
The development of Tetranectin-specific antibodies often involves immunizing hosts with recombinant Tetranectin or peptide fragments, followed by rigorous validation for specificity and sensitivity. Such antibodies enable researchers to explore Tetranectin's interactions with signaling pathways, its role in extracellular matrix modulation, and its diagnostic potential in monitoring disease progression or therapeutic responses. Ongoing studies continue to unravel its complex biology, underscoring the importance of reliable antibody reagents in both basic and clinical research.
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