| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | SL1; TAFI95; TAFI110; MGC:39976 |
| Entrez GeneID | 9013 |
| WB Predicted band size | Calculated MW: 95 kDa; Observed MW: 95 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthetic peptide of human TAF1C |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于TAF1C抗体的3篇参考文献示例(注：以下内容为模拟概括，实际文献需根据具体研究查询)：
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1. **文献名称**: *TAF1C is a component of the core factor required for RNA polymerase I transcription*
**作者**: Heix, J., Zomerdijk, J.C., Ravanpay, A., et al.
**摘要**: 本研究通过免疫沉淀和功能实验，证实TAF1C是RNA聚合酶I转录核心复合体的关键组分，利用特异性抗体揭示了其在核糖体RNA启动子识别中的必要性。
2. **文献名称**: *Dysregulation of TAF1C in neurodevelopmental disorders and cancer*
**作者**: Watanabe, M., Ohnishi, Y., Ishikawa, M.
**摘要**: 该研究通过TAF1C抗体进行免疫组化和Western blot分析，发现TAF1C表达异常与神经发育迟缓及某些癌症的细胞增殖失调相关，提示其潜在病理机制。
3. **文献名称**: *A role for TAF1C in ribosomal RNA synthesis and cellular stress response*
**作者**: Grummt, I., Langst, G., Rosenbauer, H.
**摘要**: 利用TAF1C特异性抗体进行的ChIP实验表明，TAF1C在应激条件下调控rRNA转录动态，影响细胞存活，揭示了其在应激适应中的新功能。
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如需获取真实文献，建议通过PubMed或Google Scholar以关键词“TAF1C antibody”、“RNA polymerase I TAF1C”等检索近年研究。
The TAF1C antibody is a tool used to detect TAF1C (TATA-box binding protein-associated factor 1C), a key subunit of the RNA polymerase III transcription factor complex, SL1/Selectivity Factor 1 (SL1). TAF1C plays a critical role in ribosomal RNA (rRNA) synthesis by recruiting RNA polymerase III to ribosomal DNA (rDNA) promoters, facilitating the transcription of 5S rRNA and other small RNAs. This protein is essential for maintaining cellular homeostasis, growth, and proliferation, given its central role in ribosome biogenesis.
TAF1C antibodies are widely employed in molecular biology research to study the regulation of RNA polymerase III-dependent transcription, ribosome assembly, and nucleolar organization. They are utilized in techniques such as Western blotting, immunofluorescence, and chromatin immunoprecipitation (ChIP) to assess TAF1C expression levels, localization, and interaction partners. Dysregulation of TAF1C has been implicated in diseases like ribosomopathies, certain cancers, and neurodegenerative disorders, making its study clinically relevant.
Commercially available TAF1C antibodies are typically validated for specificity and sensitivity across human, mouse, and rat models. Researchers often use these antibodies to explore mechanisms underlying cellular stress responses, aging, and pathologies linked to impaired rRNA synthesis. As a component of the basal transcriptional machinery, TAF1C remains a focal point in understanding how transcriptional dysregulation contributes to disease, highlighting the antibody's importance in both basic and applied research.
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