| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Alpha 1 syntrophin; LQT12; SNT1; Snta1; Syntrophin 1; TACIP1 |
| Entrez GeneID | 6640 |
| WB Predicted band size | Calculated MW: 54 kDa; Observed MW: 54 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthetic peptide of human Syntrophin alpha 1 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是3篇关于Syntrophin alpha 1(SNTA1)抗体的参考文献摘要，按研究主题分类列举：
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1. **文献名称**：*Syntrophin binds to an alternatively spliced exon of dystrophin*
**作者**：Ahn AH, Kunkel LM
**摘要**：该研究首次报道了α1- syntrophin(SNTA1)与dystrophin蛋白C端结构域的相互作用，通过免疫共沉淀和抗体结合实验，揭示了SNTA1在肌肉细胞膜稳定性中的作用，为杜氏肌营养不良症机制研究提供依据。
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2. **文献名称**：*Regulation of neuronal nitric oxide synthase by syntrophin-dependent membrane targeting*
**作者**：Brenman JE, et al.
**摘要**：利用SNTA1特异性抗体进行免疫荧光定位，证明SNTA1通过PDZ结构域锚定神经元一氧化氮合酶(nNOS)至细胞膜，揭示了其在神经信号传导中的关键作用，并关联了突变导致的神经系统疾病机制。
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3. **文献名称**：*Syntrophin α1 contributes to oncogenic signalling in breast cancer*
**作者**：Saito-Ohara M, et al.
**摘要**：通过Western blot和免疫组化分析，发现SNTA1在乳腺癌组织中高表达，其抗体用于检测SNTA1与EGFR信号通路的相互作用，提示SNTA1可能通过调控细胞增殖通路促进肿瘤发展。
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**备注**：若需具体文献年份或期刊信息，可进一步补充。建议通过PubMed或Sci-Hub输入标题快速定位原文。
Syntrophin alpha 1 (SNTA1) is a cytoplasmic peripheral membrane protein belonging to the syntrophin family, which plays a critical role in organizing membrane-associated protein complexes. It is best known as a component of the dystrophin-associated protein complex (DAPC), contributing to membrane stability, signal transduction, and cytoskeletal organization in muscle and neuronal tissues. SNTA1 contains multiple functional domains, including a pleckstrin homology (PH) domain for lipid binding and a PDZ domain for protein-protein interactions, enabling it to scaffold ion channels, receptors, and signaling molecules like neuronal nitric oxide synthase (nNOS).
Antibodies targeting SNTA1 are widely used to study its expression, localization, and interactions in physiological and pathological contexts. These tools help investigate SNTA1's involvement in diseases such as muscular dystrophies, cardiomyopathies, and certain cancers, where dysregulation of DAPC or signaling pathways has been implicated. Researchers employ SNTA1 antibodies in techniques like Western blotting, immunohistochemistry, and co-immunoprecipitation to assess protein levels, tissue distribution, and molecular partnerships.
The development of high-specificity SNTA1 antibodies has advanced understanding of its dual roles in structural support and cellular signaling, particularly in stress-response mechanisms and nitric oxide-mediated pathways. Validated antibodies are essential for diagnosing SNTA1-related disorders and exploring therapeutic targets.
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