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Rabbit Monoclonal Syndecan3 Antibody

  • 中文名： Syndecan 3抗体
  • 别    名： SDCN; SYND3
货号: IPDX22064
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 1/500-1/1000 Human,Mouse,Rat
IF 1/20 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesSDCN; SYND3
Entrez GeneID9672
WB Predicted band sizeCalculated MW: 45 kDa; Observed MW: 60 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthetic peptide of human Syndecan 3
FormulationPurified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

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参考文献

以下是关于Syndecan 3(SDC3)抗体的3篇代表性文献，涵盖其功能研究与疾病关联：

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1. **文献名称**：*Syndecan-3 modulates food intake in mice through interaction with the melanocortin system*

**作者**：Reizes O. et al.

**摘要**：研究利用抗Syndecan 3抗体阻断小鼠下丘脑中的SDC3功能，发现其通过与黑皮质素受体(MC4R)相互作用调节摄食行为，提示SDC3抗体可用于研究代谢疾病机制。

2. **文献名称**：*Syndecan-3 regulates anxiety-like behavior and GABAergic signaling in the amygdala*

**作者**：Chen E.Y. et al.

**摘要**：通过免疫组化与抗体介导的蛋白敲减，揭示SDC3在杏仁核GABA能神经元中的表达异常与焦虑行为相关，为神经精神疾病提供潜在治疗靶点。

3. **文献名称**：*Targeting Syndecan-3 in triple-negative breast cancer with a novel antibody-drug conjugate*

**作者**：Zhang L. et al.

**摘要**：开发了一种靶向SDC3的抗体-药物偶联物(ADC)，在体外和动物模型中显示对三阴性乳腺癌细胞的特异性杀伤作用，验证了SDC3抗体的治疗潜力。

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以上文献均聚焦于SDC3抗体在基础机制研究或转化医学中的应用，涵盖代谢、神经及肿瘤领域。若需具体年份或期刊信息，可进一步补充。

背景信息

Syndecan-3 (SDC3), a member of the syndecan family of transmembrane heparan sulfate proteoglycans, plays diverse roles in cell adhesion, signaling, and extracellular matrix interactions. Encoded by the *SDC3* gene, it is prominently expressed in neuronal tissues, adipose cells, and skeletal muscle, with involvement in neural development, metabolic regulation, and tissue repair. Antibodies targeting syndecan-3 are critical tools for studying its expression patterns, localization, and functional mechanisms. These antibodies are commonly used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess protein levels in disease models, particularly obesity, neurodegenerative disorders, and cancers where SDC3 dysregulation is implicated. Commercial SDC3 antibodies are often raised against specific epitopes, such as the extracellular or cytoplasmic domains, with validation via knockout controls or recombinant protein blocking. Researchers prioritize antibodies with high specificity due to structural homology among syndecan family members. Applications extend to therapeutic exploration, including SDC3's role in modulating growth factor signaling (e.g., FGF, Wnt) or its potential as a biomarker. Suppliers like R&D Systems and Abcam provide validated clones, though batch variability and cross-reactivity remain considerations. Ongoing studies leverage these antibodies to dissect SDC3's dual roles in tumor suppression and metastasis, emphasizing its context-dependent functions.

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