| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | SOD1; Superoxide dismutase [Cu-Zn]; Superoxide dismutase 1; hSod1 |
| Entrez GeneID | 6647 |
| WB Predicted band size | Calculated MW: 16 kDa; Observed MW: 16 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthetic peptide of human Superoxide Dismutase 1 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是3篇关于SOD1抗体的代表性文献摘要概括(虚构示例，仅作格式参考)：
1. **文献名称**：Monoclonal antibodies recognize epitopes in mutant SOD1 linked to ALS pathogenesis
**作者**：Deng, H.X., et al.
**摘要**：该研究开发了针对SOD1 G93A突变体的特异性单克隆抗体，证实其可选择性识别ALS患者脊髓组织中的错误折叠SOD1聚集体，揭示了抗体在病理诊断中的应用潜力。
2. **文献名称**：Humanized anti-SOD1 antibody reduces protein aggregates in transgenic mouse models
**作者**：Smith, G.S., & Julien, J.P.
**摘要**：通过人源化改造SOD1抗体，研究者证明其能穿透血脑屏障并促进突变SOD1的清除，显著延缓ALS模型小鼠的运动神经元退行性变。
3. **文献名称**：Epitope mapping of SOD1 autoantibodies in sporadic ALS patients
**作者**：Ezzi, S.A., et al.
**摘要**：系统性分析了散发性ALS患者血清中SOD1自身抗体的抗原表位分布，发现针对C端结构域的抗体会干扰SOD1二聚体形成，可能与疾病进展相关。
注：以上内容为模拟生成，实际文献需通过PubMed/Google Scholar以关键词"SOD1 antibody"、"amyotrophic lateral sclerosis"、"monoclonal antibody"等检索获取。
Superoxide Dismutase 1 (SOD1) is a ubiquitously expressed antioxidant enzyme that catalyzes the conversion of superoxide radicals into hydrogen peroxide and oxygen, playing a critical role in cellular defense against oxidative stress. The SOD1 gene, located on chromosome 21. encodes a 32 kDa protein primarily localized in the cytoplasm but also present in mitochondria and extracellular spaces. Mutations in SOD1 are linked to approximately 20% of familial amyotrophic lateral sclerosis (ALS) cases, where misfolded mutant SOD1 aggregates contribute to motor neuron degeneration through toxic gain-of-function mechanisms.
SOD1 antibodies are immunological tools designed to detect and quantify SOD1 protein expression, localization, and aggregation in biological samples. These antibodies are widely utilized in research applications such as Western blotting, immunohistochemistry, and immunofluorescence to study SOD1’s role in ALS pathology and oxidative stress-related diseases. Specific antibodies can distinguish between wild-type and mutant SOD1 or detect disease-associated post-translational modifications (e.g., oxidation, oligomerization). Their development has been pivotal in elucidating SOD1’s dual roles—as a protective enzyme in normal physiology versus a pathogenic driver in ALS. Additionally, SOD1 antibodies hold potential for diagnostic applications, particularly in identifying SOD1 aggregates in patient-derived samples, and for therapeutic exploration, including antibody-based strategies targeting toxic SOD1 species. Validation of these antibodies remains essential to ensure specificity, given structural similarities between SOD1 and other metalloenzymes.
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